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DHC-156

Cat. No. 8168 Submit a Review Datasheet / COA / SDS
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Description: Brachyury down modulator
Chemical Name: (E)-4-(Dimethylamino)-N-[1-[4-fluoro-3-(2,2,2-trifluoroethoxy)anilino]-6-methoxy-7-isoquinolyl]but-2-enamide
Purity: ≥98% (HPLC)
Datasheet
Citations
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Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for DHC-156

DHC-156 is a brachyury down modulator (DC50 = 4.1 μM, DMax > 99% at 10 μM). DHC-156 down modulates brachyury post-translationally, in a proteasome- and lysosome-independent manner. DHC-156 down modulation of brachyury results in an irreversible impairment of chordoma tumor cell growth.

Technical Data for DHC-156

M. Wt 492.47
Formula C24H24F4N4O3
Storage Store at -20°C
Purity ≥98% (HPLC)
PubChem ID 171038043
InChI Key SBZOWNJIUPEINK-SNAWJCMRSA-N
Smiles COC1=C(C=C2C(NC3=CC(OCC(F)(F)F)=C(C=C3)F)=NC=CC2=C1)NC(/C=C/CN(C)C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for DHC-156

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 49.25 100

Preparing Stock Solutions for DHC-156

The following data is based on the product molecular weight 492.47. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.03 mL 10.15 mL 20.31 mL
5 mM 0.41 mL 2.03 mL 4.06 mL
10 mM 0.2 mL 1.02 mL 2.03 mL
50 mM 0.04 mL 0.2 mL 0.41 mL

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References for DHC-156

References are publications that support the biological activity of the product.

Chase et al (2024) Development of a small molecule downmodulator for the transcription factor brachyury. Angew.Chem.Int.Ed.Engl. 63 e202316496 PMID: 38348945

If you know of a relevant reference for DHC-156, please let us know.

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Citations for DHC-156

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