主页 / 细胞生物学 / Signal Transduction / Heat Shock Proteins / Hsp90 / Hsp90 Inhibitors / CCT 018159

CCT 018159

Cat. No. 2435 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Hsp90 inhibitor
化学名： 4-[4-(2,3-Dihydro-1,4-benzodioxin-6-yl)-5-methyl-1H-pyrazol-3-yl]-6-ethyl-1,3-benzenediol
纯度： ≥98% (HPLC)
说明书
引用文献
评论
文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for CCT 018159

CCT 018159 is a novel inhibitor of heat shock protein 90 (Hsp90) ATPase activity (IC50 = 5.7 μM) that displays selectivity over human Hsp72 and topoisomerase II. Inhibits proliferation of HCT116 human colon tumor cells and produces upregulation of Hsp70 and downregulation of c-Raf and cdk4. More soluble than 17-AAG (Cat. No. 1515) and is independent of NQO1/DT-diaphorase and P-glycoprotein expression.

技术数据 for CCT 018159

分子量 352.39
公式 C20H20N2O4
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 171009-07-7
PubChem ID 5327091
InChI Key BBTMGPQSLSYPHE-ZHZULCJRSA-N
Smiles CCC1=C(O)C=C(O)C(=C1)C1=NNC(C)=C1C1=CC2=C(OCCO2)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for CCT 018159

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 35.24 100

制备储备液 for CCT 018159

以下数据基于产品分子量 352.39。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.84 mL 14.19 mL 28.38 mL
5 mM 0.57 mL 2.84 mL 5.68 mL
10 mM 0.28 mL 1.42 mL 2.84 mL
50 mM 0.06 mL 0.28 mL 0.57 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

产品说明书 for CCT 018159

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for CCT 018159

参考文献是支持产品生物活性的出版物。

Cheung et al (2005) The identification, synthesis, protein crystal structure and in vitro biochemical evaluation of a new 3,4-diarylpyrazole class of Hsp90 inhibitors. Bioorg.Med.Chem.Lett. 15 3338 PMID: 15955698

Dymock et al (2005) Novel, potent small-molecule inhibitors of the molecular chaperone Hsp90 discovered through structure-based design. J.Med.Chem. 48 4212 PMID: 15974572

Sharp et al (2007) In vitro biological characterization of a novel, synthetic diaryl pyrazole resorcinol class of heat shock protein 90 inhibitors. Cancer Res. 67 2206 PMID: 17332351

If you know of a relevant reference for CCT 018159, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 Hsp90 Inhibitors

关键词: CCT 018159, CCT 018159 supplier, Hsp90, inhibitors, inhibits, Heat, Shock, Protein, 90, CCT018159, 2435, Tocris Bioscience

篇 CCT 018159 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 CCT 018159 的引用文献。 您是否知道使用了 Tocris CCT 018159 的优秀论文？ 请告知我们.

CCT 018159 的评论

目前没有该产品的评论。 Be the first to review CCT 018159 and earn rewards!

Have you used CCT 018159?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Cell Cycle and DNA Damage Research Product Guide

Cell Cycle and DNA Damage Research Product Guide

This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:

  • Cell Cycle and Mitosis
  • DNA Damage Repair
  • Targeted Protein Degradation
  • Ubiquitin Proteasome Pathway
  • Chemotherapy Targets
Parkinson's Disease Poster

Parkinson's Disease Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.