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Submit ReviewCCT 031374 hydrobromide
Discontinued Product
4675 has been discontinued.
说明： Inhibits TCF-dependent transcription; lowers β-catenin levels
化学名： 1-[1,1'-Biphenyl]-4-yl-2-(2,3-dihydro-9H-imidazo[1,2-a]benzimidazol-9-yl)ethanone hydrobromide
纯度： ≥98% (HPLC)
生物活性 for CCT 031374 hydrobromide
CCT 031374 hydrobromide is an inhibitor of TCF-dependent transcription. Blocks BIO-induced β-catenin stabilization; reduces nuclear and cytosolic β-catenin levels in mouse L-cells. Inhibits growth and reduces TCF-dependent transcription in SW480 colon carcinoma cells.
技术数据 for CCT 031374 hydrobromide
| 分子量 | 434.33 |
| 公式 | C23H19N3O.HBr |
| 储存 | Desiccate at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1219184-91-4 |
| PubChem ID | 18554738 |
| InChI Key | MPILENOYNNNGKO-UHFFFAOYSA-N |
| Smiles | O=C(C4=CC=C(C5=CC=CC=C5)C=C4)CN1C3=C(C=CC=C3)N2C1=NCC2.Br |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for CCT 031374 hydrobromide
参考文献 for CCT 031374 hydrobromide
参考文献是支持产品生物活性的出版物。
Ewan et al (2010) A useful approach to identify novel small-molecule inhibitors of Wnt-dependent transcription. Cancer Res. 70 5963 PMID: 20610623
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关键词: CCT 031374 hydrobromide, CCT 031374 hydrobromide supplier, CCT031374, hydrobromide, TCF, transcription, inhibitors, inhibits, beta-catenin, b-catenin, β-catenin, stabilization, Beta-catenin, 4675, Tocris Bioscience
2 篇 CCT 031374 hydrobromide 的引用文献
引用文献是使用了 Tocris 产品的出版物。 CCT 031374 hydrobromide 的部分引用包括：
Brown et al (2019) Aging differentially modulates the Wnt pro-survival signalling pathways in vascular smooth muscle cells. Aging Cell 18 e12844 PMID: 30548452
Liu et al (2015) β-catenin signaling induces the osteoblastogenic differentiation of human pre-osteoblastic and bone marrow stromal cells mainly through the upregulation of osterix expression. Nature 36 1572 PMID: 26496941
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