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Submit ReviewCD 1530
说明： Potent and selective RARγ agonist
化学名： 4-(6-Hydroxy-7-tricyclo[3.3.1.13,7]dec-1-yl-2-naphthalenyl)benzoic acid
纯度： ≥98% (HPLC)
生物活性 for CD 1530
CD 1530 is a potent and selective RARγ receptor agonist (Ki values are 150, 1500 and 2750 nM for RARγ, RARβ and RARα receptors respectively). Activates transcriptional activity (AC50 = 1.8 nM).
化合物库 for CD 1530
CD 1530 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for CD 1530
| 分子量 | 398.49 |
| 公式 | C27H26O3 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 107430-66-0 |
| PubChem ID | 24868309 |
| InChI Key | VCQGNUWOMLYNNG-UHFFFAOYSA-N |
| Smiles | OC(C(C1(C[C@@H]2C3)C[C@H](C2)C[C@H]3C1)=C4)=CC5=C4C=C(C6=CC=C(C(O)=O)C=C6)C=C5 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for CD 1530
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 39.84 | 100 |
制备储备液 for CD 1530
以下数据基于产品分子量 398.49。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.51 mL | 12.55 mL | 25.09 mL |
| 5 mM | 0.5 mL | 2.51 mL | 5.02 mL |
| 10 mM | 0.25 mL | 1.25 mL | 2.51 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.5 mL |
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产品说明书 for CD 1530
参考文献 for CD 1530
参考文献是支持产品生物活性的出版物。
Thacher et al (2000) Therapeutic applications for ligands of retinoid receptors. Curr.Pharmaceut.Des. 6 25
If you know of a relevant reference for CD 1530, please let us know.
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关键词: CD 1530, CD 1530 supplier, Potent, selective, RARγ, RARgamma, agonists, RAMBA, Retinoic, Acid, Receptors, CD1530, 2554, Tocris Bioscience
3 篇 CD 1530 的引用文献
引用文献是使用了 Tocris 产品的出版物。 CD 1530 的部分引用包括：
Garnaas et al (2012) Rargb regulates organ laterality in a zebrafish model of right atrial isomerism. Dev Biol 372 178 PMID: 22982668
Duprey-Díaz et al (2016) Exogenous Modulation of Retinoic Acid Signaling Affects Adult RGC Survival in the Frog Visual System afterOptic Nerve Injury PLoS One 11 e0162626 PMID: 27611191
Nguyen et al (2017) Retinoic acid receptor regulation of epimorphic and homeostatic regeneration in the axolotl. Development 144 601 PMID: 28087637
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Retinoid Receptors Scientific Review
Written by Alexander Moise, this review summarizes the nature of retinoid receptors, their isotype and isoform variants and modulation of retinoid signaling. Compounds available from Tocris are listed.