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Submit ReviewCD 1530 is a potent and selective RARγ receptor agonist (Ki values are 150, 1500 and 2750 nM for RARγ, RARβ and RARα receptors respectively). Activates transcriptional activity (AC50 = 1.8 nM).
CD 1530 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
分子量 | 398.49 |
公式 | C27H26O3 |
储存 | Store at +4°C |
纯度 | ≥98% (HPLC) |
CAS Number | 107430-66-0 |
PubChem ID | 24868309 |
InChI Key | VCQGNUWOMLYNNG-UHFFFAOYSA-N |
Smiles | OC(C(C1(C[C@@H]2C3)C[C@H](C2)C[C@H]3C1)=C4)=CC5=C4C=C(C6=CC=C(C(O)=O)C=C6)C=C5 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
---|---|---|---|
溶解性 | |||
DMSO | 39.84 | 100 |
以下数据基于产品分子量 398.49。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 2.51 mL | 12.55 mL | 25.09 mL |
5 mM | 0.5 mL | 2.51 mL | 5.02 mL |
10 mM | 0.25 mL | 1.25 mL | 2.51 mL |
50 mM | 0.05 mL | 0.25 mL | 0.5 mL |
参考文献是支持产品生物活性的出版物。
Thacher et al (2000) Therapeutic applications for ligands of retinoid receptors. Curr.Pharmaceut.Des. 6 25
If you know of a relevant reference for CD 1530, please let us know.
关键词: CD 1530, CD 1530 supplier, Potent, selective, RARγ, RARgamma, agonists, RAMBA, Retinoic, Acid, Receptors, CD1530, 2554, Tocris Bioscience
引用文献是使用了 Tocris 产品的出版物。 CD 1530 的部分引用包括:
Nguyen et al (2017) Retinoic acid receptor regulation of epimorphic and homeostatic regeneration in the axolotl. Development 144 601 PMID: 28087637
Garnaas et al (2012) Rargb regulates organ laterality in a zebrafish model of right atrial isomerism. Dev Biol 372 178 PMID: 22982668
Duprey-Díaz et al (2016) Exogenous Modulation of Retinoic Acid Signaling Affects Adult RGC Survival in the Frog Visual System afterOptic Nerve Injury PLoS One 11 e0162626 PMID: 27611191
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