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Submit ReviewCD 3254
说明： Potent and selective RXRα agonist
化学名： 3-[4-Hydroxy-3-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)phenyl]-2-propenoic acid
纯度： ≥97% (HPLC)
生物活性 for CD 3254
CD 3254 is a selective RXRα agonist; exhibits no activity at RARα, RARβ or RARγ receptors. CD 3254 can promote chemical reprogramming of mouse fibroblasts. In a fast chemical reprogramming protocol, it promotes reprogramming of foetal mouse dorsal fibroblasts (MDFs) and adult mouse lung fibroblasts (MLFs) to iPS cells within 12 days.
化合物库 for CD 3254
CD 3254 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for CD 3254
| 分子量 | 364.48 |
| 公式 | C24H28O3 |
| 储存 | Store at -20°C |
| 纯度 | ≥97% (HPLC) |
| CAS Number | 196961-43-0 |
| PubChem ID | 44566110 |
| InChI Key | DYLLZSVPAUUSSB-VQHVLOKHSA-N |
| Smiles | CC1(C)C2=C(C=C(C3=C(O)C=CC(/C=C/C(O)=O)=C3)C(C)=C2)C(C)(C)CC1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for CD 3254
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 36.45 | 100 | |
| ethanol | 36.45 | 100 |
制备储备液 for CD 3254
以下数据基于产品分子量 364.48。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.74 mL | 13.72 mL | 27.44 mL |
| 5 mM | 0.55 mL | 2.74 mL | 5.49 mL |
| 10 mM | 0.27 mL | 1.37 mL | 2.74 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.55 mL |
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产品说明书 for CD 3254
参考文献 for CD 3254
参考文献是支持产品生物活性的出版物。
Pogenberg et al (2005) Characterization of the interaction between retinoic acid receptor/retinoid X receptor (RAR/RXR) heterodimers and transcriptional coactivators through structural and fluorescence anisotropy studies. J.Biol.Chem. 280 1625 PMID: 15528208
le Maire et al (2009) Activation of RXR-PPAR heterodimers by organotin environmental endocrine disruptors. EMBO.Rep. 10 367 PMID: 19270714
Nahoum et al (2007) Modulators of the structural dynamics of the retinoid X receptor to reveal receptor function. Proc.Natl.Acad.Sci. 104 17323 PMID: 17947383
Jin et al (2023) Harnessing endogenous transcription factors directly by small molecules for chemically induced pluripotency inception. Proc.Natl.Acad.Sci. 23 120 PMID: 37192170
Chen et al (2023) A fast chemical reprogramming system promotes cell identity transition through a diapause-like state. Nat.Cell Biol. 25 1146 PMID: 37550515
If you know of a relevant reference for CD 3254, please let us know.
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关键词: CD 3254, CD 3254 supplier, Potent, selective, RXR, agonists, CD3254, aRXR, alphaRXR, αRXR, retinoid, X, receptor, fast, chemical, reprogramming, iPS, Retinoid, Receptor, Stem, Cell, Reprogramming, 3302, Tocris Bioscience
1 篇 CD 3254 的引用文献
引用文献是使用了 Tocris 产品的出版物。 CD 3254 的部分引用包括：
Wang et al (2017) Retinoic acid inhibits white adipogenesis by disrupting GADD45A-mediated Zfp423 DNA demethylation. J Mol Cell Biol 9 338 PMID: 28992291
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Retinoid Receptors Scientific Review
Written by Alexander Moise, this review summarizes the nature of retinoid receptors, their isotype and isoform variants and modulation of retinoid signaling. Compounds available from Tocris are listed.