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CDK8/19i

Cat. No. 7372 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent and selective CDK8 and CDK19 inhibitor; maintains pluripotency of mouse PSCs in culture
化学名： N-Propyl-3-(4-pyridinyl)imidazo[1,2-b]pyridazin-6-amine
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for CDK8/19i

CDK8/19i is a potent and selective CDK8 and CDK19 inhibitor (IC50 values are 2.9 and 14.1 nM, respectively). CDK8/19i maintains pluripotency of mouse PSCs in culture. It induces the formation of dome-shaped colonies and upregulates Nanog-GFP reporter and endogenous Nanog expression in mouse ESCs in vitro.

化合物库 for CDK8/19i

CDK8/19i is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. 了解 Tocris 化合物库的更多信息。

技术数据 for CDK8/19i

分子量 253.3
公式 C14H15N5
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 923596-52-5
PubChem ID 68488430
InChI Key XTMROGQLIVGYKF-UHFFFAOYSA-N
Smiles CCCNC1=NN2C(C=C1)=NC=C2C3=CC=NC=C3

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for CDK8/19i

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 25.33 100
ethanol 25.33 100

制备储备液 for CDK8/19i

以下数据基于产品分子量 253.3。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.95 mL 19.74 mL 39.48 mL
5 mM 0.79 mL 3.95 mL 7.9 mL
10 mM 0.39 mL 1.97 mL 3.95 mL
50 mM 0.08 mL 0.39 mL 0.79 mL

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参考文献 for CDK8/19i

参考文献是支持产品生物活性的出版物。

Lynch et al (2020) Global hyperactivation of enhancers stabilizes human and mouse naive pluripotency through inhibition of CDK8/19 Mediator kinases. Nat.Cell.Bio. 22 1223 PMID: 32989249

If you know of a relevant reference for CDK8/19i, please let us know.

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关键词: CDK8/19i, CDK8/19i supplier, cyclin, dependent, kinases, inhibitors, inhibits, CDK8, CDK19, stem, cells, pluripotency, pluripotent, maintenance, self-renewal, potent, selective, Stem, Cell, Proliferation, Transcriptional, CDKs, 7372, Tocris Bioscience

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