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Submit ReviewCE3F4
说明： Noncompetitive Epac1 inhibitor
化学名： 5,7-Dibromo-6-fluoro-3,4-dihydro-2-methyl-1(2H)-quinolinecarboxaldehyde
纯度： ≥98% (HPLC)
生物活性 for CE3F4
CE3F4 is a noncompetitive Epac1 inhibitor. Blocks Epac-induced Rap activation and prevents isoprenaline-induced autophagy flux in cardiomyocytes. Has no effect on PKA activity in the presence of cAMP.
化合物库 for CE3F4
CE3F4 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for CE3F4
| 分子量 | 351.01 |
| 公式 | C11H10Br2FNO |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 143703-25-7 |
| PubChem ID | 21781066 |
| InChI Key | ZZLQPWXVZCPUGC-UHFFFAOYSA-N |
| Smiles | BrC1=C(F)C(Br)=C(CCC(C)N2C=O)C2=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for CE3F4
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 35.1 | 100 | |
| ethanol | 17.55 | 50 |
制备储备液 for CE3F4
以下数据基于产品分子量 351.01。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.85 mL | 14.24 mL | 28.49 mL |
| 5 mM | 0.57 mL | 2.85 mL | 5.7 mL |
| 10 mM | 0.28 mL | 1.42 mL | 2.85 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.57 mL |
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产品说明书 for CE3F4
参考文献 for CE3F4
参考文献是支持产品生物活性的出版物。
Laurent et al (2015) Exchange protein directly activated by cAMP 1 promotes autophagy during cardiomyocyte hypertrophy. Cardiovasc.Res. 105 55 PMID: 25411381
Courilleau et al (2012) Identification of a tetrahydroquinoline analog as a pharmacological inhibitor of the cAMP-binding protein Epac. J.Biol.Chem. 287 44192 PMID: 23139415
Chen et al (2022) The peripheral Epac1/p-Cav-1 pathway underlies the disruption of the vascular endothelial barrier following skin/muscle incision and retraction-induced chronic postsurgical pain. Ann.Transl.Med. 10 1377
If you know of a relevant reference for CE3F4, please let us know.
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关键词: CE3F4, CE3F4 supplier, noncompetitive, Epac1, inhibitors, inhibits, autophagy, Exchange, proteins, Rap, guanine, nucleotide, exchange, factor, 3, RAPGEF3, cAMP, GEFI, EPAC, 4793, Tocris Bioscience
4 篇 CE3F4 的引用文献
引用文献是使用了 Tocris 产品的出版物。 CE3F4 的部分引用包括：
Chen et al (2022) The peripheral Epac1/p-Cav-1 pathway underlies the disruption of the vascular endothelial barrier following skin/muscle incision and retraction-induced chronic postsurgical pain. Ann.Trans.Med. 10 1377
Paul A et al (2020) Inhibition of IRF4 in dendritic cells by PRR-independent and -dependent signals inhibit Th2 and promote Th17 responses. Elife 9 PMID: 32014112
Jakobsen et al (2019) Soluble adenylyl cyclase-mediated cAMP signaling and the putative role of PKA and EPAC in cerebral mitochondrial function. J Neurosci Res 97 1018 PMID: 31172581
Derek C et al (2021) Regulation of Mitochondrial Function by Epac2 Contributes to Acute Inflammatory Hyperalgesia. J Neurosci 41 2883-2898 PMID: 33593853
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