CE3F4

Name: CE3F4
Brand: Tocris Bioscience
SKU: 4793

Cat. No. 4793 4 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4793 has been discontinued.

View all EPAC products.

说明： Noncompetitive Epac1 inhibitor

化学名： 5,7-Dibromo-6-fluoro-3,4-dihydro-2-methyl-1(2H)-quinolinecarboxaldehyde

纯度： ≥98% (HPLC)

说明书

引用文献 (4)

生物活性技术数据说明书参考文献

生物活性 for CE3F4

CE3F4 is a noncompetitive Epac1 inhibitor. Blocks Epac-induced Rap activation and prevents isoprenaline-induced autophagy flux in cardiomyocytes. Has no effect on PKA activity in the presence of cAMP.

化合物库 for CE3F4

CE3F4 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for CE3F4

分子量	351.01
公式	C₁₁H₁₀Br₂FNO
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	143703-25-7
PubChem ID	21781066
InChI Key	ZZLQPWXVZCPUGC-UHFFFAOYSA-N
Smiles	BrC1=C(F)C(Br)=C(CCC(C)N2C=O)C2=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for CE3F4

分析证书/产品说明书

化学品安全技术说明书

参考文献 for CE3F4

参考文献是支持产品生物活性的出版物。

Laurent et al (2015) Exchange protein directly activated by cAMP 1 promotes autophagy during cardiomyocyte hypertrophy. Cardiovasc.Res. 105 55 PMID: 25411381

Courilleau et al (2012) Identification of a tetrahydroquinoline analog as a pharmacological inhibitor of the cAMP-binding protein Epac. J.Biol.Chem. 287 44192 PMID: 23139415

Chen et al (2022) The peripheral Epac1/p-Cav-1 pathway underlies the disruption of the vascular endothelial barrier following skin/muscle incision and retraction-induced chronic postsurgical pain. Ann.Transl.Med. 10 1377

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关键词: CE3F4, CE3F4 supplier, noncompetitive, Epac1, inhibitors, inhibits, autophagy, Exchange, proteins, Rap, guanine, nucleotide, exchange, factor, 3, RAPGEF3, cAMP, GEFI, EPAC, 4793, Tocris Bioscience