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Ceefourin 1

Cat. No. 5867 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Selective MRP4 inhibitor
化学名： 5-[(2-Benzothiazolylthio)methyl]-2,4-dihydro-4-methyl-3H-1,2,4-triazole-3-thione
纯度： ≥98% (HPLC)
说明书
引用文献
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生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Ceefourin 1

Ceefourin 1 is a selective MRP (multidrug resistance-associated protein) 4 inhibitor (IC50 = 2.6 μM). Selective for MRP4 over P-gp, MRP1 and ABCG2. Sensitizes MRP4 over-expressing cells to SN 38 (Cat. No. 2684). Ceefourin 1 inhibits cAMP efflux from acute myeloid leukemia cells (AML) and promotes apoptosis in combination with Histamine (Cat. No. 3545).

技术数据 for Ceefourin 1

分子量 294.42
公式 C11H10N4S3
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 315702-40-0
PubChem ID 704306
InChI Key KVNBVHCJAUXKPJ-UHFFFAOYSA-N
Smiles CN1C(NN=C1CSC2=NC3=CC=CC=C3S2)=S

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Ceefourin 1

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 29.44 100

制备储备液 for Ceefourin 1

以下数据基于产品分子量 294.42。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.4 mL 16.98 mL 33.97 mL
5 mM 0.68 mL 3.4 mL 6.79 mL
10 mM 0.34 mL 1.7 mL 3.4 mL
50 mM 0.07 mL 0.34 mL 0.68 mL

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参考文献 for Ceefourin 1

参考文献是支持产品生物活性的出版物。

Cheung et al (2014) High-throughput screening identifies Ceefourin 1 and Ceefourin 2 as highly selective inhibitors of multidrug resistance protein 4 (MRP4). Biochem.Pharmacol. 91 97 PMID: 24973542

Sahores et al (2023) Ceefourin-1, a MRP4/ABCC4 inhibitor, induces apoptosis in AML cells enhanced by histamine. Biochim.Biophys.Acta 1867 130322 PMID: 36773726

If you know of a relevant reference for Ceefourin 1, please let us know.

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关键词: Ceefourin 1, Ceefourin 1 supplier, multidrug, resistance-associated, protein, 4, MRP4, inhibitors, inhibits, transporters, ABCC4, AML, acute, myeloid, leukemia, apoptosis, Multidrug, Transporters, Other, Apoptosis, 5867, Tocris Bioscience

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