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Ceftriaxone disodium salt

Cat. No. 3732 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Neuroprotective; increases EAAT2 expression and activity
化学名： 7-[[(2Z)-2-(2-Amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid disodium salt
纯度： ≥98% (HPLC)
说明书
引用文献
评论 (1)
文献 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for Ceftriaxone disodium salt

β-lactam antibiotic. Displays neuroprotective activity in vivo via upregulation and increased activity of the EAAT2 glutamate transporter.

技术数据 for Ceftriaxone disodium salt

分子量 598.54
公式 C18H16N8Na2O7S3
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 104376-79-6
PubChem ID 9601224
InChI Key FDRNWTJTHBSPMW-ZJTMPOFJSA-L
Smiles [Na+].[Na+].CO\N=C(/C(=O)NC1C(=O)N2C(C([O-])=O)=C(CSC3=NC(=O)C([O-])=NN3C)CS[C@]12[H])C1=CSC(N)=N1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Ceftriaxone disodium salt

分析证书/产品说明书
化学品安全技术说明书

参考文献 for Ceftriaxone disodium salt

参考文献是支持产品生物活性的出版物。

Rothstein et al (2005) β-Lactam antibiotics offer neuroprotection by increasing glutamate transporter expression. Nature 433 73 PMID: 15635412

Rawls et al (2007) The beta-lactam antibiotic, ceftriaxone, attenuates morphine-evoked hyperthermia in rats. Br.J.Pharmacol. 151 1095 PMID: 17592517

Lipski et al (2007) Neuroprotective potential of ceftri. in in vitro models of stroke. Neuroscience 146 617 PMID: 17363173

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关键词: Ceftriaxone disodium salt, Ceftriaxone disodium salt supplier, GLT-1, EAAT2, glutamate, transporters, activators, expression, Excitatory, Amino, Acid, Transporters, Monoamine, Neurotransmitter, antibiotics, Glutamate, Antibiotics, 3732, Tocris Bioscience

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Increase GLT1 expression.
By Anonymous on 01/25/2018
种属： Human

Used it to increase protein expression of GLT1 in mouse brain. It worked very well and easily dissolves in saline.

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