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Submit ReviewCELT-211
说明： Fluorescent serotonin 5HT2B receptor ligand for HTS
纯度： ≥95% (HPLC)
生物活性 for CELT-211
CELT-211 is a potent and selective fluorescent h5HT2B serotonin receptor ligand. It shows full selectivity for h5HT2B over h5HT2A, h5HT2C (Ki values is 56.3 nM for h5HT2B receptors in radioligand binding assay). Excitation and emission maxima (λ) are 589 and 616 nm, respectively. Wavelengths are compatible with use as an acceptor dye in TR-FRET assays, together with the CoraFluor™ 1 (Cat. No. 7920) TR-FRET donor.
Add 82 μL of assay buffer containing 1% of DMSO to obtain a 100 μM stock solution, and use 250 nM as a working concentration.
Scientific Data
Fluorescence Imaging
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Application of CELT-211 in CHO cells expressing the human 5HT2BR. CHO cells expressing the human 5HT2BR labelled with CELT-211 (pink) at 56 nM and Hoechst 33342 (blue) (catalog # 5117) without (A) or with (B) 5-HT (50 µM) preincubation.
许可信息
Sold under license from Celtarys Research
Optical Data for CELT-211
| λabs | 589 nm |
|---|---|
| λem | 616 nm |
| Application | Time-resolved fluorescence energy transfer (TR-FRET) |
Plan Your Experiments
Use our spectra viewer to interactively plan your experiments, assessing multiplexing options. View the excitation and emission spectra for our fluorescent dye range and other commonly used dyes.
Spectral Viewer
技术数据 for CELT-211
| 分子量 | 1330.22 |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for CELT-211
参考文献 for CELT-211
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.