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Ceritinib

Cat. No. 6905 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Highly potent ALK inhibitor; also potently inhibits IR, IGF1R, STK22D and FLT3
别名： LDK378
化学名： 5-Chloro-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-N2-[5-methyl-2-(1-methylethoxy)-4-(4-piperidinyl)phenyl]-2,4-pyrimidinediamine
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Ceritinib

Ceritinib is a highly potent anaplastic lymphoma kinase (ALK) inhibitor (IC50 = 0.2 nM). Also displays potent inhibition of insulin receptor (IR), insulin-like growth factor receptor 1 (IGF1R), serine/threonine-protein kinase STK22D and FLT3 (IC50 values are 7, 8, 23 and 60 nM, respectively). Inhibits tumor growth in Karpas299 and H2228 rat xenograft models.

技术数据 for Ceritinib

分子量 558.14
公式 C28H36ClN5O3S
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 1032900-25-6
PubChem ID 57379345
InChI Key VERWOWGGCGHDQE-UHFFFAOYSA-N
Smiles CC(C)OC1=C(NC2=NC=C(Cl)C(NC3=C(C=CC=C3)[S](=O)(=O)C(C)C)=N2)C=C(C)C(=C1)C1CCNCC1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Ceritinib

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 2.79 5 温和加热
ethanol 2.79 5 温和加热

制备储备液 for Ceritinib

以下数据基于产品分子量 558.14。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.05 mM 35.83 mL 179.17 mL 358.33 mL
0.25 mM 7.17 mL 35.83 mL 71.67 mL
0.5 mM 3.58 mL 17.92 mL 35.83 mL
2.5 mM 0.72 mL 3.58 mL 7.17 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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参考文献 for Ceritinib

参考文献是支持产品生物活性的出版物。

Marsilje et al (2013) Synthesis, structure-activity relationships, and in vivo efficacy of the novel potent and selective anaplastic lymphoma kinase (ALK) inhibitor 5-chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diam J.Med.Chem. 56 5675 PMID: 23742252

If you know of a relevant reference for Ceritinib, please let us know.

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关键词: Ceritinib, Ceritinib supplier, LDK378, ALK, inhibitors, inhibits, highly, potent, Anaplastic, lymphoma, kinase, insulin, receptor, InsR, insulin-like, growth, factor, IGF1R, FLT3, STK22D, Insulin, and, Receptors, 6905, Tocris Bioscience

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