Cetirizine dihydrochloride

Name: Cetirizine dihydrochloride
Brand: Tocris Bioscience
SKU: 2577

Cat. No. 2577 4 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

2577 has been discontinued.

View all Histamine H<sub>1</sub> Receptors products.

说明： Selective H₁ antagonist

别名： P 071

化学名： [2-[4-[(4-Chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]acetic acid dihydrochloride

纯度： ≥99% (HPLC)

说明书

引用文献 (4)

文献 (1)

生物活性技术数据说明书参考文献

生物活性 for Cetirizine dihydrochloride

Cetirizine dihydrochloride is a histamine H₁ receptor antagonist that displays selectivity over other receptors at concentrations up to 10 μM. A non-sedating antihistamine that inhibits histamine release and eosinophil chemotaxis during secondary phase allergic response. Inhibits activation of eosinophils, neutrophils and monocytes in vivo.

技术数据 for Cetirizine dihydrochloride

分子量	461.81
公式	C₂₁H₂₅ClN₂O₃.2HCl
储存	Desiccate at RT
纯度	≥99% (HPLC)
CAS Number	83881-52-1
PubChem ID	55182
InChI Key	PGLIUCLTXOYQMV-UHFFFAOYSA-N
Smiles	Cl.Cl.OC(=O)COCCN1CCN(CC1)C(C1=CC=CC=C1)C1=CC=C(Cl)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Cetirizine dihydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Cetirizine dihydrochloride

参考文献是支持产品生物活性的出版物。

Campoli-Richards et al (1990) Cetirizine. A review of its pharmacological properties and clinical potential in allergic rhinitis, pollen-induced asthma, and chronic urticaria. Drugs 40 762 PMID: 1981354

Snowman and Snyder (1990) Cetirizine: actions on neurotransmitter receptors. J.Allergy.Clin.Immunol. 86 1025 PMID: 1979798

Walsh et al (1991) Effects of cetirizine on human eosinophil and neutrophil activation in vitro. Int.Arch.Allergy Appl.Immunol. 95 158 PMID: 1682275

按标靶查看相关产品

按产品操作查看相关产品

查看全部 Histamine H₁ Receptor Antagonists

关键词: Cetirizine dihydrochloride, Cetirizine dihydrochloride supplier, Selective, H1, antagonists, Receptors, Histamine, histaminergic, P071, P, 071, 2577, Tocris Bioscience

4 篇 Cetirizine dihydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Cetirizine dihydrochloride 的部分引用包括：

Kim et al (2013) Effects of histamine on cultured interstitial cells of cajal in murine small intestine. Korean J Physiol Pharmacol 17 149 PMID: 23626477

Lenz et al (2018) Mast Cells in the Developing Brain Determine Adult Sexual Behavior. J Neurosci 38 8044 PMID: 30093566

Ito et al (2015) PARK2-mediated mitophagy is involved in regulation of HBEC senescence in COPD pathogenesis. PLoS One 11 547 PMID: 25714760

Kemp et al (2014) DNA repair synthesis and ligation affect the processing of excised oligonucleotides generated by human nucleotide excision repair. J Biol Chem 289 26574 PMID: 25107903