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Submit ReviewCetrorelix acetate 最新
说明： Potent GnRH receptor antagonist
纯度： ≥95% (HPLC)
生物活性 for Cetrorelix acetate
Cetrorelix acetate is a potent gonadotropin-releasing hormone (GnRH) receptor antagonist (KD = 0.202 nM, IC50 = 1.21 nM). Suppresses production of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary gland, which inhibits ovulation. Exhibits antiproliferative effects and displays efficacy against hormone-sensitive cancers in vivo. Also exhibits anxiolytic and antidepressant activity in vivo.
技术数据 for Cetrorelix acetate
| 分子量 | 1431.06 |
| 公式 | C70H92ClN17O14 |
| 序列 |
XFXSYXLRPA (Modifications: X-1 = D-2-Nal and N-terminal Ac, Phe-2 = 4-Cl-D-Phe, X-3 = 3-(3-Pyridyl)-D-Ala), X-6 = D-Cit, Ala-10 = D-Ala and C-terminal amide) |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 145672-81-7 |
| PubChem ID | 25074887 |
| InChI Key | SBNPWPIBESPSIF-MHWMIDJBSA-N |
| Smiles | CC(C[C@@H](C(N[C@H](C(N1CCC[C@H]1C(N[C@@H](C(N)=O)C)=O)=O)CCCNC(N)=N)=O)NC([C@H](NC([C@@H](NC([C@@H](NC([C@H](NC([C@H](NC([C@H](NC(C)=O)CC2=CC3=CC=CC=C3C=C2)=O)CC4=CC=C(Cl)C=C4)=O)CC5=CN=CC=C5)=O)CO)=O)CC6=CC=C(C=C6)O)=O)CCCNC(N)=O)=O)C |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Cetrorelix acetate
| 溶解性 | Soluble to 1 mg/ml in 0.02 M acetic acid |
产品说明书 for Cetrorelix acetate
参考文献 for Cetrorelix acetate
参考文献是支持产品生物活性的出版物。
Beckers et al (1997) Characterization of gonadotropin-releasing hormone analogs based on a sensitive cellular luciferase reporter gene assay. Anal.Biochem. 251 17 PMID: 9300077
Gründker and Emons (2003) Role of gonadotropin-releasing hormone (GnRH) in ovarian cancer. Reprod.Biol.Endocrinol. 1 65 PMID: 14594454
Telegdy et al (2009) Effects of the LHRH antagonist cetro. on the brain function in mice. Neuropeptides 43 229 PMID: 19375162
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关键词: Cetrorelix acetate, Cetrorelix acetate supplier, Potent, GnRH, antagonists, Peptide, Receptors, Gonadotropin-releasing, Hormone, gonadotrophin, Gonadotrophin-Releasing, 8821, Tocris Bioscience
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