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CGP 3466B maleate

Cat. No. 2966 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： GAPDH inhibitor; neuroprotective
别名： TCH 346 maleate
化学名： N-(Dibenz[b,f]oxepin-10-ylmethyl)-N-Methyl-N-(2-propynyl)amine maleate
纯度： ≥99% (HPLC)
说明书
引用文献 (1)
评论
文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for CGP 3466B maleate

CGP 3466B maleate is an orally active glyceraldehyde-3-phosphate dehydrogenase (GAPDH) inhibitor. Exhibits antiapoptotic activity via inhibition of GAPDH nuclear translocation and mitochondrial complex 1-dependent H2O2 release. CGP 3466B inhibits colon cancer proliferation in vitro and displays neuroprotective activity in vivo.

化合物库 for CGP 3466B maleate

CGP 3466B maleate is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for CGP 3466B maleate

分子量 391.42
公式 C19H17NO.C4H4O4
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 200189-97-5
PubChem ID 9821821
InChI Key SQAZQLMBEHYFJA-BTJKTKAUSA-N
Smiles O=C(O)/C=C\C(O)=O.CN(CC#C)CC2=CC1=CC=CC=C1OC3=C2C=CC=C3

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for CGP 3466B maleate

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 3.91 10
DMSO 39.14 100

制备储备液 for CGP 3466B maleate

以下数据基于产品分子量 391.42。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.55 mL 12.77 mL 25.55 mL
5 mM 0.51 mL 2.55 mL 5.11 mL
10 mM 0.26 mL 1.28 mL 2.55 mL
50 mM 0.05 mL 0.26 mL 0.51 mL

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产品说明书 for CGP 3466B maleate

分析证书/产品说明书
化学品安全技术说明书

参考文献 for CGP 3466B maleate

参考文献是支持产品生物活性的出版物。

Andringa et al (2003) TCH346 prevents motor symptoms and loss of striatal FDOPA uptake in bilaterally MPTP-treated primates. Neurobiol.Dis. 14 205 PMID: 14572443

Sagot et al (2000) An orally active anti-apoptotic molecule (CGP 3466B) preserves mitochondria and enhances survival in an animal model of motoneuron disease. Br.J.Pharmacol. 131 721 PMID: 11030721

Zoccarato et al (2008) Clorgyline and other propargylamine derivatives as inhibitors of succinate-dependent H2O2 release at NADH:UBIQUINONE oxidoreductase (Complex I) in brain mitochondria. J.Bioenerg.Biomembr. 40 289 PMID: 18763029

Bazzocco et al (2015) Highly expressed genes in rapidly proliferating tumor cells as new targets for colorectal cancer treatment. Clin.Cancer Res. 21 3685 PMID: 25944804

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关键词: CGP 3466B maleate, CGP 3466B maleate supplier, glyceraldehyde-3-phosphate, dehydrogenase, GAPDH, inhibitors, inhibits, CGP3466B, TCH346, TCH, 346, maleate, Other, Dehydrogenases, 2966, Tocris Bioscience

1 篇 CGP 3466B maleate 的引用文献

引用文献是使用了 Tocris 产品的出版物。 CGP 3466B maleate 的部分引用包括：

Xu et al (2013) Behavioral effects of cocaine mediated by nitric oxide-GAPDH transcriptional signaling. Neuron 78 623 PMID: 23719162

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