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Submit ReviewCGP 37849
说明： Potent and selective NMDA antagonist
化学名： (E)-(±)-2-Amino-4-methyl-5-phosphono-3-pentenoic acid
纯度： ≥99% (HPLC)
生物活性 for CGP 37849
CGP 37849 is a potent, selective and competitive NMDA receptor antagonist (Ki = 35 nM). Anticonvulsive following oral administration in vivo.
技术数据 for CGP 37849
| 分子量 | 209.14 |
| 公式 | C6H12NO5P |
| 储存 | Desiccate at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 127910-31-0 |
| PubChem ID | 5950212 |
| InChI Key | BDYHNCZIGYIOGJ-DUXPYHPUSA-N |
| Smiles | NC(C(O)=O)/C=C(C)/CP(O)(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for CGP 37849
参考文献 for CGP 37849
参考文献是支持产品生物活性的出版物。
Fagg et al (1990) CGP 37849 and CGP 39551: novel and potent competitive N-MthD.-asparate receptor antagonists with oral activity. Br.J.Pharmacol. 99 791 PMID: 1972895
Loscher and Honack (1991) Anticonvulsant and behavioural effects of two novel competitive N-MthD.-aspartic acid receptor antagonists, CGP 37849 and CGP 39551, in the kindling model of epilepsy. Comparison with MK-801 and carbamaz. J.Pharmacol.Exp.Ther. 256 432 PMID: 1671593
Pozza et al (1990) Electrophysiological characterization of a novel potent and orally active NMDA receptor antagonist: CGP 37849 and its ethylester CGP 39551. Eur.J.Pharmacol. 182 91 PMID: 1976098
If you know of a relevant reference for CGP 37849, please let us know.
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关键词: CGP 37849, CGP 37849 supplier, Potent, selective, NMDA, antagonists, Glutamate, Receptors, N-Methyl-D-Aspartate, iGlur, Ionotropic, CGP37849, 1469, Tocris Bioscience
3 篇 CGP 37849 的引用文献
引用文献是使用了 Tocris 产品的出版物。 CGP 37849 的部分引用包括：
Kim et al (2012) Decreased afferent excitability contributes to synaptic depression during high-frequency stimulation in hippocampal area CA1. J Neurophysiol 108 1965 PMID: 22773781
Owen and Grover (2015) Activity-dependent differences in function between proximal and distal Schaffer collaterals. J Neurophysiol 113 3646 PMID: 25855695
Sowa et al (2015) Prenatal stress enhances excitatory synaptic transmission and impairs long-term potentiation in the frontal cortex of adult offspring rats. PLoS One 10 e0119407 PMID: 25749097
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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