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CGP 42112

Cat. No. 2569 3 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Selective, high affinity AT2 ligand
纯度： ≥95% (HPLC)
说明书
引用文献 (3)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for CGP 42112

CGP 42112 is a selective, high affinity angiotensin AT2 receptor ligand (Ki = 0.24 nM). Displays agonistic properties at proximal tubule AT2 receptors, causes Na+, K+-ATPase inhibition and sodium excretion. Antagonizes Ang-II induced contractions in rabbit aortic rings (IC50 = 1850 nM).

技术数据 for CGP 42112

分子量 1052.2
公式 C52H69N13O11
序列 YKHPI

(Modifications: Tyr-1 = N-α-Nicotinoyl, Lys-2 = Lys-(N-α-Z-Arg))
储存 Store at -20°C
纯度 ≥95% (HPLC)
CAS Number 127060-75-7
PubChem ID 123794
InChI Key UXGNARZDONUMMK-LRMQDCNJSA-N
Smiles CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC1=CNC=N1)NC(=O)[C@H](CCCCNC(=O)[C@H](CCCNC(N)=N)NC(=O)OCC1=CC=CC=C1)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)C1=CN=CC=C1)C(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for CGP 42112

溶解性 Soluble to 1 mg/ml in water

产品说明书 for CGP 42112

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for CGP 42112

参考文献是支持产品生物活性的出版物。

Naveri (1995) The role of angiotensin receptor subtypes in cerebrovascular regulation in the rat. Acta.Physiol.Scand.Suppl. 630 1 PMID: 8610501

Hakam and Hussain (2006) Angiotensin II AT2 receptors inhibit proximal tubular Na+-K+-ATPase activity via a NO/cGMP-dependent pathway. Am.J.Physiol.Renal Physiol. 290 F1430 PMID: 16380464

Criscione et al (1990) Binding characteristics and vascular effects of various angiotensin II antagonists. J.Cardiovas.Pharmacol. 16 S56

If you know of a relevant reference for CGP 42112, please let us know.

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关键词: CGP 42112, CGP 42112 supplier, Selective, high, affinity, AT2, ligands, Receptors, Angiotensin, CGP42112, 2569, Tocris Bioscience

3 篇 CGP 42112 的引用文献

引用文献是使用了 Tocris 产品的出版物。 CGP 42112 的部分引用包括：

Nostramo et al (2012) Regulation of angiotensin II type 2 receptor gene expression in the adrenal medulla by acute and repeated immobilization stress. Stroke 215 291 PMID: 22911895

Li et al (2012) Perinatal nicotine exposure increases vulnerability of hypoxic-ischemic brain injury in neonatal rats: role of angiotensin II receptors. BMC Cancer 43 2483 PMID: 22738920

Raffai et al (2016) Angiotensin-(1-7) selectively induces relaxation and modulates endothelium-dependent dilation in mesenteric arteries of salt-fed rats Journal of Vascular Research 53 105 PMID: 27676088

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