CGP 74514 dihydrochloride

Cat. No. 5472 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent CDK1 inhibitor

化学名： rel-N²-[(1R,2S)-2-Aminocyclohexyl]-N⁶-(3-chlorophenyl)-9-ethyl-9H-purine-2,6-diamine dihydrochloride

纯度： ≥98% (HPLC)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for CGP 74514 dihydrochloride

CGP 74514 dihydrochloride is a potent cdk1 inhibitor (IC₅₀ = 25 nM). Reduces Akt phosphorylation and increases mitochondrial damage in leukemia cells in vitro in combination with LY 294002.

技术数据 for CGP 74514 dihydrochloride

分子量	458.82
公式	C₁₉H₂₄ClN₇.2HCl
储存	Desiccate at RT
纯度	≥98% (HPLC)
PubChem ID	121513864
InChI Key	YFAKNNUHXLCNLG-FZMMWMHASA-N
Smiles	CCN2C1=NC(N[C@@H]4CCCC[C@@H]4N)=NC(NC3=CC(Cl)=CC=C3)=C1N=C2.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for CGP 74514 dihydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	22.94	50
	DMSO	45.88	100

制备储备液 for CGP 74514 dihydrochloride

以下数据基于产品分子量 458.82。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.18 mL	10.9 mL	21.8 mL
5 mM	0.44 mL	2.18 mL	4.36 mL
10 mM	0.22 mL	1.09 mL	2.18 mL
50 mM	0.04 mL	0.22 mL	0.44 mL

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产品说明书 for CGP 74514 dihydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for CGP 74514 dihydrochloride

参考文献是支持产品生物活性的出版物。

Yu et al (2013) The lethal effects of pharmacological cyclin-dependent kinase inhibitors in human leukemia cells proceed through a phosphatidylinositol 3-kinase/Akt-dependent process. Cancer Res. 63 1822 PMID: 12702569

Furet et al (2000) Structure-based design of potent CDK1 inhibitors derived from olomoucine. J.Comput.Aided Mol.Des. 14 403 PMID: 10896313

If you know of a relevant reference for CGP 74514 dihydrochloride, please let us know.

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