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Submit ReviewCGRP 8-37 (rat)
说明： CGRP antagonist
别名： Calcitonin Gene-Related Peptide 8-37 (rat)
纯度： ≥95% (HPLC)
生物活性 for CGRP 8-37 (rat)
CGRP 8-37 (rat) is a peptide antagonist for CGRP1 receptors.
技术数据 for CGRP 8-37 (rat)
| 分子量 | 3127.5 |
| 公式 | C138H224N42O41 |
| 序列 |
VTHRLAGLLSRSGGVVKDNFVPTNVGSEAF (Modification: Phe-30 = C-terminal amide) |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 129121-73-9 |
| PubChem ID | 90479762 |
| InChI Key | HZKKKBMPFPSSKZ-QZMRZBIOSA-N |
| Smiles | [H]N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for CGRP 8-37 (rat)
| 溶解性 | Soluble to 1 mg/ml in water |
产品说明书 for CGRP 8-37 (rat)
参考文献 for CGRP 8-37 (rat)
参考文献是支持产品生物活性的出版物。
Poyner (1995) Pharmacology of receptors for calcitonin gene-related peptide and amylin. TiPS 16 424 PMID: 8578616
Poyner et al (1998) Structural determinants for binding to CGRP receptors expressed by human SK-N-MC and Col 29 cells: studies with chimeric and other peptides. Br.J.Pharmacol. 124 1659 PMID: 9756381
Wisskirchen et al (1998) Pharmacological characterization of CGRP receptors mediating relaxation of the rat pulmonary artery and inhibition of twitch responses of the rat vas deferens. Br.J.Pharmacol. 123 1673 PMID: 9605575
If you know of a relevant reference for CGRP 8-37 (rat), please let us know.
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关键词: CGRP 8-37 (rat), CGRP 8-37 (rat) supplier, CGRP1, receptor, antagonist, CGRP, receptors, AM1, AM2, calcitonin-gene, related, peptide, CGRP8-37, (rat), Calcitonin, Gene-Related, Peptide, 8-37, and, Related, Receptors, 1169, Tocris Bioscience
5 篇 CGRP 8-37 (rat) 的引用文献
引用文献是使用了 Tocris 产品的出版物。 CGRP 8-37 (rat) 的部分引用包括：
Cowie et al (2018) Optogenetic Inhibition of CGRPα Sensory Neurons Reveals Their Distinct Roles in Neuropathic and Incisional Pain. J Neurosci 38 5807 PMID: 29925650
Tozzi et al (2012) Critical role of calcitonin gene-related peptide receptors in cortical spreading depression. Proc Natl Acad Sci U S A 109 18985 PMID: 23112192
Khodorova et al (2009) Early and late contributions of glutamate and CGRP to mechanical sensitization by endothelin-1. J Pain 10 740 PMID: 19559390
Holland et al (2005) Orexin 1 receptor activation attenuates neurogenic dural vasodilation in an animal model of trigeminovascular nociception. J Cell Mol Med 315 1380 PMID: 16160082
Zhang et al (2019) Role of intraganglionic transmission in the trigeminovascular pathway. Mol Pain 15 1744806919836570 PMID: 30784351
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