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Submit ReviewCGS 12066B dimaleate
说明： 5-HT1B agonist
化学名： 7-Trifluoromethyl-4-(4-methyl-1-piperazinyl)pyrrolo[1,2-a]-quinoxaline dimaleate
纯度： ≥98% (HPLC)
生物活性 for CGS 12066B dimaleate
CGS 12066B dimaleate is a 5-HT1B full agonist, 10-fold selective over 5-HT1A and 1000-fold selective over 5-HT2C receptors. Centrally active following systemic administration.
技术数据 for CGS 12066B dimaleate
| 分子量 | 566.49 |
| 公式 | C17H17F3N4.2C4H4O4 |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 109028-10-6 |
| PubChem ID | 9915956 |
| InChI Key | HTEVMLYDEWVIQE-SPIKMXEPSA-N |
| Smiles | O=C(O)/C=C\C(O)=O.O=C(O)/C=C\C(O)=O.FC(C1=CC3=C(N2C=CC=C2C(N4CCN(CC4)C)=N3)C=C1)(F)F |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for CGS 12066B dimaleate
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 2.83 | 5 | |
| DMSO | 22.66 | 40 |
制备储备液 for CGS 12066B dimaleate
以下数据基于产品分子量 566.49。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.4 mM | 4.41 mL | 22.07 mL | 44.13 mL |
| 2 mM | 0.88 mL | 4.41 mL | 8.83 mL |
| 4 mM | 0.44 mL | 2.21 mL | 4.41 mL |
| 20 mM | 0.09 mL | 0.44 mL | 0.88 mL |
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产品说明书 for CGS 12066B dimaleate
参考文献 for CGS 12066B dimaleate
参考文献是支持产品生物活性的出版物。
Neale et al (1987) Biochemical and pharmacological characterization of CGS 12066B, a selective serotonin-1B agonist. Eur.J.Pharmacol. 136 1 PMID: 3496228
Schoeffter and Hoyer (1989) Interaction of arylpiperazines with 5-HT1A, 5-HT1B, 5-HT1C and 5-HT1D receptors: do discriminatory 5-HT1B receptor ligands exist? Naunyn Schmiedebergs Arch.Pharmacol. 339 675 PMID: 2770889
Tomkins and O'Neill (2000) Effect of 5-HT1B receptor ligands on self-administration of ethanol in an operant procedure in rats. Pharmacol.Biochem.Behav. 66 129 PMID: 10837852
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关键词: CGS 12066B dimaleate, CGS 12066B dimaleate supplier, 5-HT1B, agonists, Serotonin, Receptors, 5-HT1, CGS12066B, dimaleate, 0638, Tocris Bioscience
3 篇 CGS 12066B dimaleate 的引用文献
引用文献是使用了 Tocris 产品的出版物。 CGS 12066B dimaleate 的部分引用包括：
Gadgaard & Jensen (2020) Functional characterization of 5-HT1A and 5-HT1B serotonin receptor signaling through G-protein-activated inwardly rectifying K+ channels in a fluorescence-based membrane potential assay. Biochem Pharmcol 175 PMID: 32088264
Khatri et al (2014) Lasting neurobehavioral abnormalities in rats after neonatal activation of serotonin 1A and 1B receptors: possible mechanisms for serotonin dysfunction in autistic spectrum disorders. Psychopharmacology (Berl) 231 1191 PMID: 23975037
Maciag et al (2006) Evidence that the deficit in sexual behavior in adult rats neonatally exposed to cital. is a consequence of 5-HT1 receptor stimulation during development. Brain Res 1125 171 PMID: 17101120
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