CH 223191

Cat. No. 3858 13 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent aryl hydrocarbon receptor (AhR) antagonist

化学名： 1-Methyl-N-[2-methyl-4-[2-(2-methylphenyl)diazenyl]phenyl-1H-pyrazole-5-carboxamide

纯度： ≥98% (HPLC)

引用文献 (13)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for CH 223191

CH 223191 is a potent aryl hydrocarbon receptor (AhR) antagonist (IC₅₀ = 30 nM). Exhibits no AhR agonist-like activity (at concentrations up to 100 μM). Inhibits 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-induced AhR-dependent transcription in vitro and reduces TCDD-induced toxicity in vivo. Attenuates Th17 differentiation of naive CD4 T cells and promotes expansion of hematopoietic stem cells in vitro.

化合物库 for CH 223191

CH 223191 is also offered as part of the Tocriscreen Stem Cell Library. 了解 Tocris 化合物库的更多信息。

技术数据 for CH 223191

分子量	333.39
公式	C₁₉H₁₉N₅O
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	301326-22-7
PubChem ID	3091786
InChI Key	LKTNEXPODAWWFM-UHFFFAOYSA-N
Smiles	CC1=C(/N=N/C2=CC=C(NC(C3=CC=NN3C)=O)C(C)=C2)C=CC=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for CH 223191

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	33.34	100
	ethanol	3.33	10

制备储备液 for CH 223191

以下数据基于产品分子量 333.39。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	3 mL	15 mL	29.99 mL
5 mM	0.6 mL	3 mL	6 mL
10 mM	0.3 mL	1.5 mL	3 mL
50 mM	0.06 mL	0.3 mL	0.6 mL

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产品说明书 for CH 223191

分析证书/产品说明书

化学品安全技术说明书

参考文献 for CH 223191

参考文献是支持产品生物活性的出版物。

Kim et al (2006) Novel compound 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazo-phenyl)-amide (CH-223191) prevents 2,3,7,8-TCDD-induced toxicity by antagonizing the aryl hydrocarbon receptor. Mol.Pharmacol. 69 1871 PMID: 16540597

Veldhoen et al (2009) Natural agonists for aryl hydrocarbon receptor in culture medium are essential for optimal differentiation of TH17 T cells. J.Exp.Med. 206 43 PMID: 19114668

Dubrovska et al (2012) CXCR4 activation maintains a stem cell population in tamoxifen-resistant breast cancer cells through AhR signalling. Br.J.Cancer. 107 43 PMID: 22644306

Boitano et al (2010) Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells. Science 329 1345 PMID: 20688981

If you know of a relevant reference for CH 223191, please let us know.

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