CHMFL-FLT3-122

Name: CHMFL-FLT3-122
Brand: Tocris Bioscience
SKU: 5800

Cat. No. 5800 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

5800 has been discontinued.

View all FLT3 products.

说明： Potent and selective FLT3 inhibitor

化学名： 1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-(dimethylamino)-ethanone

说明书

引用文献

生物活性技术数据说明书参考文献

生物活性 for CHMFL-FLT3-122

CHMFL-FLT3-122 is a potent and selective FLT3 inhibitor (IC₅₀ = 40 nM). Exhibits >10-fold and 170-fold selectivity for FLT3 over BTK kinase and c-KIT kinase, respectively in vitro. Induces apoptosis by arresting cell cycle in G₀/G₁ phase in vitro. Suppresses tumor growth in an AML xenograft model. Modestly orally bioavailable.

技术数据 for CHMFL-FLT3-122

分子量	471.55
公式	C₂₆H₂₉N₇O₂
储存	Store at +4°C
CAS Number	1839150-56-9
PubChem ID	121513893
InChI Key	IZNAFSDUTMZGSF-LJQANCHMSA-N
Smiles	NC1=C2C(N([C@@H]3CCCN(C(CN(C)C)=O)C3)N=C2C4=CC=C(OC5=CC=CC=C5)C=C4)=NC=N1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for CHMFL-FLT3-122

分析证书/产品说明书

化学品安全技术说明书

参考文献 for CHMFL-FLT3-122

参考文献是支持产品生物活性的出版物。

Li et al (2015) Discovery of (R)-1-(3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-2-(dimethylamino)ethanone (CHMFL-FLT3-122) as a potent and orally available FLT3 kinase inhibitor for FLT3-ITD positive acute myeloid leu J.Med.Chem. 58 9625 PMID: 26630553

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关键词: CHMFL-FLT3-122, CHMFL-FLT3-122 supplier, Potent, selective, FLT, inhibitors, inhibits, AML, acute, myeloid, leukemia, cell, cycle, FLT3, Cell, Cycle, Inhibitors, Apoptosis, Inducers, 5800, Tocris Bioscience

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