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Submit ReviewCHPG Sodium salt
说明： Selective mGlu5 agonist; sodium salt of CHPG (Cat. No. 1049)
化学名： (RS)-2-Chloro-5-hydroxyphenylglycine sodium salt
纯度： ≥99% (HPLC)
生物活性 for CHPG Sodium salt
CHPG Sodium salt is a sodium salt of the selective mGlu5 agonist CHPG (Cat. No. 1049).
化合物库 for CHPG Sodium salt
CHPG Sodium salt is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for CHPG Sodium salt
| 分子量 | 223.59 |
| 公式 | C8H7ClNNaO3 |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 1303993-73-8 |
| PubChem ID | 52974246 |
| InChI Key | KZRZZIISUUINJT-UHFFFAOYSA-M |
| Smiles | [Na+].NC(C([O-])=O)C1=CC(O)=CC=C1Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for CHPG Sodium salt
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 11.18 | 50 | |
| DMSO | 11.18 | 50 |
制备储备液 for CHPG Sodium salt
以下数据基于产品分子量 223.59。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 8.94 mL | 44.72 mL | 89.45 mL |
| 2.5 mM | 1.79 mL | 8.94 mL | 17.89 mL |
| 5 mM | 0.89 mL | 4.47 mL | 8.94 mL |
| 25 mM | 0.18 mL | 0.89 mL | 1.79 mL |
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产品说明书 for CHPG Sodium salt
参考文献 for CHPG Sodium salt
参考文献是支持产品生物活性的出版物。
Doherty et al (1997) (RS)-2-Chloro-5-hydroxyphenylglycine (CHPG) activates mGlu5, but not mGlu1, receptors expressed in CHO cells and potentiates NMDA responses in the hippocampus. Neuropharmacology 36 265 PMID: 9144665
Salt et al (1999) Antagonism of the mGlu5 agonist 2-chloro-5-hydroxyphenylglycine by the novel selective mGlu5 antagonist 6-methyl-2-(phenylethynyl)-pyridine (MPEP) in the thalamus. Br.J.Pharmacol. 127 1057 PMID: 10455248
Bao et al (2001) Selective mGluR5 receptor antagonist or agonist provides neuroprotection in a rat model of focal cerebral ischaemia. Brain Res. 922 173 PMID: 11743947
If you know of a relevant reference for CHPG Sodium salt, please let us know.
关键词: CHPG Sodium salt, CHPG Sodium salt supplier, mGlu5, mGluR5, selective, agonist, mGlur, Group, I, Receptors, Glutamate, Metabotropic, (Metabotropic), 3695, Tocris Bioscience
2 篇 CHPG Sodium salt 的引用文献
引用文献是使用了 Tocris 产品的出版物。 CHPG Sodium salt 的部分引用包括：
Hyuk Soo et al (2021) Metabotropic Glutamate Receptor 5 in Natural Killer Cells Attenuates Liver Fibrosis by Exerting Cytotoxicity to Activated Stellate Cells. Hepatology 74 2170-2185 PMID: 33932306
Yangyang et al (2021) CHPG enhances BDNF and myelination in cuprizone-treated mice through astrocytic metabotropic glutamate receptor 5. Glia 69 1950-1965 PMID: 33811383
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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