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Ciglitazone

Cat. No. 1307 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

1307 has been discontinued.

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说明： Selective PPARγ agonist
化学名： 5-[[4-[(1-Methylcyclohexyl)methoxy]phenyl]methyl]-2,4-thiazolidinedione
纯度： ≥99% (HPLC)
说明书
引用文献 (2)
评论
生物活性 技术数据 说明书 参考文献

生物活性 for Ciglitazone

Ciglitazone is a selective agonist at PPARγ (peroxisome proliferator-activated receptor γ). Activates PPARγ with an EC50 value of 3 μM in vitro, and is at least 33-fold selective over PPARα and δ. Antihyperglycemic in vivo.

技术数据 for Ciglitazone

分子量 333.44
公式 C18H23NO3S
储存 Store at RT
纯度 ≥99% (HPLC)
CAS Number 74772-77-3
PubChem ID 2987927
InChI Key LOBCDGHHHHGHFA-UHFFFAOYSA-N
Smiles CC1(COC2=CC=C(CC3SC(=O)NC3=O)C=C2)CCCCC1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for Ciglitazone

参考文献是支持产品生物活性的出版物。

Jh (1999) Thiazolidinediones - the new Ins enhancers. Clin.Exp.Hypertens. 21 157 PMID: 10052651

Willson et al (1996) The structure-activity relationship between peroxisome proliferator receptor γ agonism and the antihyperglycemic activity of thiazolidinediones. J.Med.Chem. 39 665 PMID: 8576907

Xin et al (1999) Peroxisome proliferator-activated receptor γ ligands are potent inhibitors of angiogenesis in vitro and in vivo. J.Biol.Chem. 274 9116 PMID: 10085162

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关键词: Ciglitazone, Ciglitazone supplier, Selective, PPARγ, PPARgamma, agonists, Peroxisome, Proliferating-activated, Receptors, 1307, Tocris Bioscience

2 篇 Ciglitazone 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Ciglitazone 的部分引用包括：

Emmans et al (2004) Regulation of cellular processes by PPARgamma ligands in neuroblastoma cells is modulated by the level of retinoblastoma protein expression. Biochem Soc Trans 32 840 PMID: 15494029

Zeitouni et al (2008) Pharmaceutical induction of ApoE secretion by multipotent mesenchymal stromal cells (MSCs). BMC Biotechnol 8 75 PMID: 18823563

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