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Ciglitazone

Cat. No. 1307 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

1307 has been discontinued.

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说明： Selective PPARγ agonist
化学名： 5-[[4-[(1-Methylcyclohexyl)methoxy]phenyl]methyl]-2,4-thiazolidinedione
纯度： ≥99% (HPLC)
说明书
引用文献 (2)
评论
生物活性 技术数据 说明书 参考文献

生物活性 for Ciglitazone

Ciglitazone is a selective agonist at PPARγ (peroxisome proliferator-activated receptor γ). Activates PPARγ with an EC50 value of 3 μM in vitro, and is at least 33-fold selective over PPARα and δ. Antihyperglycemic in vivo.

技术数据 for Ciglitazone

分子量 333.44
公式 C18H23NO3S
储存 Store at RT
纯度 ≥99% (HPLC)
CAS Number 74772-77-3
PubChem ID 2987927
InChI Key LOBCDGHHHHGHFA-UHFFFAOYSA-N
Smiles CC1(COC2=CC=C(CC3SC(=O)NC3=O)C=C2)CCCCC1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for Ciglitazone

参考文献是支持产品生物活性的出版物。

Jh (1999) Thiazolidinediones - the new Ins enhancers. Clin.Exp.Hypertens. 21 157 PMID: 10052651

Willson et al (1996) The structure-activity relationship between peroxisome proliferator receptor γ agonism and the antihyperglycemic activity of thiazolidinediones. J.Med.Chem. 39 665 PMID: 8576907

Xin et al (1999) Peroxisome proliferator-activated receptor γ ligands are potent inhibitors of angiogenesis in vitro and in vivo. J.Biol.Chem. 274 9116 PMID: 10085162

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关键词: Ciglitazone, Ciglitazone supplier, Selective, PPARγ, PPARgamma, agonists, Peroxisome, Proliferating-activated, Receptors, 1307, Tocris Bioscience

2 篇 Ciglitazone 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Ciglitazone 的部分引用包括：

Zeitouni et al (2008) Pharmaceutical induction of ApoE secretion by multipotent mesenchymal stromal cells (MSCs). BMC Biotechnol 8 75 PMID: 18823563

Emmans et al (2004) Regulation of cellular processes by PPARgamma ligands in neuroblastoma cells is modulated by the level of retinoblastoma protein expression. Biochem Soc Trans 32 840 PMID: 15494029

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