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Cilnidipine

Cat. No. 2629 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Dual CaV1.x and CaV2.x blocker
别名： FRC 8653
化学名： 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl (2E)-3-phenyl-2-propenyl ester
纯度： ≥99% (HPLC)
说明书
引用文献
评论 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Cilnidipine

Cilnidipine is a dual L- and N-type calcium channel blocker that displays antihypertensive, sympatholytic and neuroprotective activity. Lowers mean blood pressure and reduces the size of cerebral infarction in the rat model of focal brain ischemia.

化合物库 for Cilnidipine

Cilnidipine is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for Cilnidipine

分子量 492.52
公式 C27H28N2O7
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 132203-70-4
PubChem ID 2752
InChI Key KJEBULYHNRNJTE-UHFFFAOYSA-N
Smiles COCCOC(=O)C1=C(C)NC(C)=C(C1C1=CC=CC(=C1)[N+]([O-])=O)C(=O)OCC=CC1=CC=CC=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Cilnidipine

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 49.25 100
ethanol 4.92 10

制备储备液 for Cilnidipine

以下数据基于产品分子量 492.52。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.03 mL 10.15 mL 20.3 mL
5 mM 0.41 mL 2.03 mL 4.06 mL
10 mM 0.2 mL 1.02 mL 2.03 mL
50 mM 0.04 mL 0.2 mL 0.41 mL

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参考文献 for Cilnidipine

参考文献是支持产品生物活性的出版物。

Murai et al (2000) Preferential inhibition of L- and N-type calcium channels in the rat hippocampal neurons by cilnidipine. Brain Res. 854 6 PMID: 10784100

Takahara et al (2004) Neuroprotective effects of a dual L/N-type Ca2+ channel blocker cilnidipine in the rat focal brain ischemia model. Biol.Pharm.Bull. 27 1388 PMID: 15340224

Nap et al (2004) The evaluation of the N-type channel blocking properties of cilnidipine and other voltage-dependent calcium antagonists. Fund.Clin.Pharmacol. 18 309

If you know of a relevant reference for Cilnidipine, please let us know.

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关键词: Cilnidipine, Cilnidipine supplier, Ca2+, channel, blockers, dual, L/N-type, Calcium, CaV, Channels, L-Type, N-Type, voltage-gated, voltage-dependent, FRC8653, FRC, 8653, Cav1.x, Cav2.x, 2629, Tocris Bioscience

篇 Cilnidipine 的引用文献

引用文献是使用了 Tocris 产品的出版物。

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Cilnidipine 的评论

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The effect of Cilnidipine was studied on the N-type Ca2+ channel.
By Anonymous on 02/12/2019
种属： Human

The effect of Cilnidipine was studied on the N-type Ca2+ channel. Due to its blocking action at the N-type and L-type calcium channel, cilnidipine dilates both arterioles and venules, reducing the pressure in the capillary bed.

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