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Submit ReviewCilostamide
说明： PDE3 inhibitor
别名： OCP 3689
化学名： N-Cyclohexyl-N-methyl-4-(1,2-dihydro-2-oxo-6-quinolyloxy)butyramide
纯度： ≥97% (HPLC)
生物活性 for Cilostamide
Cilostamide is a selective inhibitor of type III phosphodiesterase (PDE3). Displays moderate selectivity for PDE3A isozyme vs. PDE3B (IC50 values are 0.027 and 0.050 μM for PDE3A and PDE3B respectively). Inhibits ADP-induced platelet aggregation (IC50 = 16.8 μM); antithrombotic.
技术数据 for Cilostamide
| 分子量 | 342.44 |
| 公式 | C20H26N2O3 |
| 储存 | Store at RT |
| 纯度 | ≥97% (HPLC) |
| CAS Number | 68550-75-4 |
| PubChem ID | 2753 |
| InChI Key | UIAYVIIHMORPSJ-UHFFFAOYSA-N |
| Smiles | CN(C1CCCCC1)C(=O)CCCOC1=CC=C2NC(=O)C=CC2=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Cilostamide
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 6.85 | 20 温和加热 |
制备储备液 for Cilostamide
以下数据基于产品分子量 342.44。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 14.6 mL | 73.01 mL | 146.01 mL |
| 1 mM | 2.92 mL | 14.6 mL | 29.2 mL |
| 2 mM | 1.46 mL | 7.3 mL | 14.6 mL |
| 10 mM | 0.29 mL | 1.46 mL | 2.92 mL |
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产品说明书 for Cilostamide
参考文献 for Cilostamide
参考文献是支持产品生物活性的出版物。
Hidaki et al (1979) Selective inhibitor of platelet cyclic adenosine monophosphate phosphodiesterase, cilostamide, inhibits platelet aggregation. J.Pharmacol.Exp.Ther. 211 26 PMID: 226672
Sudo et al (2000) Potent effects of novel anti-platelet aggregatory cilostamide analogues on recombinant cyclic nucleotide phosphodiesterase isozyme activity. Biochem.Pharmacol. 59 347 PMID: 10644042
Christensen and Torphy (1994) Isozyme-selective phosphodiesterase inhibitors as antiasthmatic agents. Annu.Rep.Med.Chem. 29 185
If you know of a relevant reference for Cilostamide, please let us know.
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关键词: Cilostamide, Cilostamide supplier, PDE3, inhibitors, inhibits, Phosphodiesterases, OCP3689, OCP, 3689, 0915, Tocris Bioscience
5 篇 Cilostamide 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Cilostamide 的部分引用包括：
Brunet et al (2013) Increased intracellular magnesium attenuates β-adrenergic stimulation of the cardiac Ca(V)1.2 channel. J Gen Physiol 141 85 PMID: 23250865
Merino et al (2015) Glucagon Increases Beating Rate but Not Contractility in Rat Right Atrium. Comparison with isoprote. PLoS One 10 e0132884 PMID: 26222156
Ørstavik et al (2015) The inotropic effect of the active metabolite of levosimendan, OR-1896, is mediated through inhibition of PDE3 in rat ventricular myocardium. J Biol Chem 10 e0115547 PMID: 25738589
Hubert et al (2014) Alteration of vascular reactivity in heart failure: role of phosphodiesterases 3 and 4. Br J Pharmacol 171 5361 PMID: 25048877
Zhai et al (2012) β-Adrenergic cAMP signals are predominantly regulated by phosphodiesterase type 4 in cultured adult rat aortic smooth muscle cells. PLoS One 7 e47826 PMID: 23094097
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