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CIM 0216

Cat. No. 5521 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Selective TRPM3 agonist
化学名： 3,4-Dihydro-N-(5-methyl-3-isoxazolyl)-α-phenyl-1(2H)-quinolineacetamide
纯度： ≥98% (HPLC)
说明书
引用文献 (2)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for CIM 0216

CIM 0216 is a selective TRPM3 agonist. Exhibits selectivity for TRPM3 over TRPM1, TRPM2 and TRPM4-8. Stimulates insulin release from pancreatic islet cells in vitro. Evokes nocifensive behavior in mice.

化合物库 for CIM 0216

CIM 0216 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for CIM 0216

分子量 347.41
公式 C21H21N3O2
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 1031496-06-6
PubChem ID 42887770
InChI Key KSEXDSJYVSEVGF-UHFFFAOYSA-N
Smiles O=C(NC1=NOC(C)=C1)C(C2=CC=CC=C2)N(CCC3)C4=C3C=CC=C4

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for CIM 0216

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 34.74 100

制备储备液 for CIM 0216

以下数据基于产品分子量 347.41。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.88 mL 14.39 mL 28.78 mL
5 mM 0.58 mL 2.88 mL 5.76 mL
10 mM 0.29 mL 1.44 mL 2.88 mL
50 mM 0.06 mL 0.29 mL 0.58 mL

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产品说明书 for CIM 0216

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for CIM 0216

参考文献是支持产品生物活性的出版物。

Held et al (2015) Activation of TRPM3 by a potent synthetic ligand reveals a role in peptide release. Proc.Natl.Acad.Sci.U.S.A. 112 E1363 PMID: 25733887

If you know of a relevant reference for CIM 0216, please let us know.

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关键词: CIM 0216, CIM 0216 supplier, CIM0216, TRPM3, transient, potential, membrane, ion, channels, pain, insulin, TRPM, 5521, Tocris Bioscience

2 篇 CIM 0216 的引用文献

引用文献是使用了 Tocris 产品的出版物。 CIM 0216 的部分引用包括：

Xi et al (2021) ATF4 selectively regulates heat nociception and contributes to kinesin-mediated TRPM3 trafficking. Nat Commun 12 1401 PMID: 33658516

Rubil and Thiel (2017) Activation of gene transcription via CIM0216, a synthetic ligand of transient receptor potential melastatin-3 (TRPM3) channels. Channels (Austin) 11 79 PMID: 27356187

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