CIMBA hydrochloride

Cat. No. 7812 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Potent and selective G protein-coupled estrogen receptor (GPER) antagonist

化学名： N-[2-Cyclohexyl-4-(1-methylethyl)phenyl]-4-methoxybenzenemethanamine hydrochloride

纯度： ≥98% (HPLC)

通路 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for CIMBA hydrochloride

CIMBA hydrochloride is a potent G protein-coupled estrogen receptor (GPER) antagonist (IC₅₀ = 75 nM). In vivo, it prevents the formation of estrogen-induced cholesterol gallstones by inhibiting the GPER pathway in female ovariectomized mice.

许可信息

Sold under licence from Saint Louis University.

技术数据 for CIMBA hydrochloride

分子量	373.97
公式	C₂₃H₃₁NO.HCl
储存	Store at -20°C
纯度	≥98% (HPLC)
InChI Key	KWVXXQOTMDKOID-UHFFFAOYSA-N
Smiles	CC(C)C(C=C1C2CCCCC2)=CC=C1NCC(C=C3)=CC=C3OC.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for CIMBA hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	37.4	100
	ethanol	37.4	100

制备储备液 for CIMBA hydrochloride

以下数据基于产品分子量 373.97。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.67 mL	13.37 mL	26.74 mL
5 mM	0.53 mL	2.67 mL	5.35 mL
10 mM	0.27 mL	1.34 mL	2.67 mL
50 mM	0.05 mL	0.27 mL	0.53 mL

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产品说明书 for CIMBA hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for CIMBA hydrochloride

参考文献是支持产品生物活性的出版物。

DeLeon et al (2020) A novel GPER antagonist protects against the formation of estrogen-induced cholesterol gallstones in female mice. J.Lipid Res. 61 767 PMID: 32127396

If you know of a relevant reference for CIMBA hydrochloride, please let us know.

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Estrogen (GPER) Receptors

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