Cinanserin hydrochloride

Cat. No. 0460 3 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Selective 5-HT₂ antagonist; also 3C-like proteinase inhibitor

化学名： N-[2-[[3-(Dimethylamino)propyl]thio]phenyl]-3-phenyl-2-propenamide hydrochloride

纯度： ≥99% (HPLC)

引用文献 (3)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Cinanserin hydrochloride

Cinanserin hydrochloride is a 5-HT₂ antagonist. Also inhibits 3C-like proteinase (3CL^pro; M^pro). Inhibits replication of SARS-CoV.

技术数据 for Cinanserin hydrochloride

分子量	376.94
公式	C₂₀H₂₄N₂OS.HCl
储存	Desiccate at RT
纯度	≥99% (HPLC)
CAS Number	54-84-2
PubChem ID	6433141
InChI Key	LXGJPDKYMJJWRB-IERUDJENSA-N
Smiles	O=C(/C=C/C2=CC=CC=C2)NC1=CC=CC=C1SCCCN(C)C.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Cinanserin hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	water		50

制备储备液 for Cinanserin hydrochloride

以下数据基于产品分子量 376.94。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.5 mM	5.31 mL	26.53 mL	53.06 mL
2.5 mM	1.06 mL	5.31 mL	10.61 mL
5 mM	0.53 mL	2.65 mL	5.31 mL
25 mM	0.11 mL	0.53 mL	1.06 mL

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产品说明书 for Cinanserin hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Cinanserin hydrochloride

参考文献是支持产品生物活性的出版物。

Leysen et al (1981) Receptor binding profile of R-41-468, a novel antagonist at 5HT₂ receptors. Life Sci. 28 1015 PMID: 6261070

Pierce et al (1992) Molecular structure basis of ligand selectivity for 5-HT₂ versus 5-HT_1C cortical receptors. Naunyn Schmiedebergs Arch.Pharmacol. 346 4 PMID: 1407003

Chen et al (2005) Cinanserin is an inhibitor of the 3C-like proteinase of the severe acute respiratory syndrome coronavirus and strongly reduces virus replication in vitro. J.Virol. 79 7095 PMID: 15890949

If you know of a relevant reference for Cinanserin hydrochloride, please let us know.

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3 篇 Cinanserin hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Cinanserin hydrochloride 的部分引用包括：

Seeburg et al (2004) Frequency-dependent modulation of retinogeniculate transmission by serotonin. J Neurosci 24 10950 PMID: 15574745

Buznikov et al (2010) A putative 'pre-nervous' endocannabinoid system in early echinoderm development. Dev Neurosci 32 1 PMID: 19907129

Gautam et al (2016) Tryptophan hydroxylase 1 and 5-HT7 receptor preferentially expressed in triple-negative breast cancer promote cancer progression through autocrine serotonin signaling. Mol Cancer 15 75 PMID: 27871326

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