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Submit ReviewCINPA 1
Discontinued Product
5605 has been discontinued.
View all Constitutive Androstane Receptor products.
说明： Potent CAR antagonist
化学名： Ethyl [5-[(diethylamino)acetyl]-10,11-dihydro-5H-dibenz[b,f]azepin-3-yl]carbamate
纯度： ≥98% (HPLC)
生物活性 for CINPA 1
CINPA 1 is a potent CAR antagonist (IC50 = 70 nM). Exhibits >90-fold selectivity for CAR over pregnane X receptor (PXR). Also selective over a panel of other nuclear receptors including FXR, LXR, PPARγ and RXR.
化合物库 for CINPA 1
CINPA 1 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for CINPA 1
| 分子量 | 395.49 |
| 公式 | C23H29N3O3 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 102636-74-8 |
| PubChem ID | 969470 |
| InChI Key | AYQBYSPEGRYKFA-UHFFFAOYSA-N |
| Smiles | O=C(CN(CC)CC)N1C2=C(C=CC=C2)CCC3=C1C=C(NC(OCC)=O)C=C3 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for CINPA 1
参考文献 for CINPA 1
参考文献是支持产品生物活性的出版物。
Cherian et al (2015) CINPA1 is an inhibitor of constitutive androstane receptor that does not activate pregnane X receptor. Mol.Pharmacol. 87 878 PMID: 25762023
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关键词: CINPA 1, CINPA 1 supplier, CINPA1, CAR, constitutive, androstane, receptors, potent, antagonists, Constitutive, Androstane, Receptor, 5605, Tocris Bioscience
1 篇 CINPA 1 的引用文献
引用文献是使用了 Tocris 产品的出版物。 CINPA 1 的部分引用包括：
Boussadia et al (2016) Lack of CAR impacts neuronal function and cerebrovascular integrity in vivo. Exp Neurol 283 39 PMID: 27240521
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