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说明： Potentiator of NMDA receptors containing GluN2C/GluN2D
化学名： (3-Chlorophenyl) [3,4-dihydro-6,7-dimethoxy-1-[(4-methoxyphenoxy)methyl]-2(1H)-isoquinolinyl]methanone
纯度： ≥98% (HPLC)
生物活性 for CIQ
CIQ is a subunit-selective potentiator of NMDA receptors containing the GluN2C (formally NR2C) or GluN2D (formally NR2D) subunit. Increases channel opening efficiency and enhances NMDA receptor responses.
Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.
化合物库 for CIQ
CIQ is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for CIQ
| 分子量 | 467.94 |
| 公式 | C26H26ClNO5 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 486427-17-2 |
| PubChem ID | 4231127 |
| InChI Key | VYMILMYEENZHAR-UHFFFAOYSA-N |
| Smiles | O=C(C3=CC(Cl)=CC=C3)N2C(COC4=CC=C(OC)C=C4)C1=CC(OC)=C(OC)C=C1CC2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for CIQ
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 46.79 | 100 |
制备储备液 for CIQ
以下数据基于产品分子量 467.94。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.14 mL | 10.69 mL | 21.37 mL |
| 5 mM | 0.43 mL | 2.14 mL | 4.27 mL |
| 10 mM | 0.21 mL | 1.07 mL | 2.14 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.43 mL |
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产品说明书 for CIQ
参考文献 for CIQ
参考文献是支持产品生物活性的出版物。
Mullasseril et al (2010) A subunit-selective potentiator of NR2C- and NR2D-containing NMDA receptors. Nat.Commun. 1 1 PMID: 20975674
If you know of a relevant reference for CIQ, please let us know.
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关键词: CIQ, CIQ supplier, NMDA, receptors, potentiators, NR2C, NR2D, subunits, enhances, opening, efficiency, GluN2C, GluN2D, Receptors, 4105, Tocris Bioscience
2 篇 CIQ 的引用文献
引用文献是使用了 Tocris 产品的出版物。 CIQ 的部分引用包括：
Kashima and Grueter (2017) Toll-like receptor 4 deficiency alters nucleus accumbens synaptic physiology and drug reward behavior. Proc Natl Acad Sci U S A. 114 8865 PMID: 28760987
Hedegaard et al (2012) Molecular pharmacology of human NMDA receptors. Neurochem Int 61 601 PMID: 22197913
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*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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