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cis-22a

Cat. No. 7118 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： TRPV6 inhibitor
化学名： 1-[cis-4-(3-Methylphenyl)cyclohexyl]-4-(3-pyridinyl)piperazine ditrifluoroacetate
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for cis-22a

cis-22a is a TRPV6 inhibitor (IC50 = 0.32 μM), which exhibits selectivity against related TRPV channels and calcium channels. cis-22a displays antiproliferative effects on T47D human breast cancer cells.

化合物库 for cis-22a

cis-22a is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for cis-22a

分子量 563.54
公式 C22H29N3.2CF3CO2H
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1819366-84-1
InChI Key UMKPISXYUQWXJJ-XWOHEVPJSA-N
Smiles CC1=CC=CC([C@@H]2CC[C@H](N3CCN(C4=CN=CC=C4)CC3)CC2)=C1.OC(C(F)(F)F)=O.OC(C(F)(F)F)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for cis-22a

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 56.35 100
DMSO 56.35 100

制备储备液 for cis-22a

以下数据基于产品分子量 563.54。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.77 mL 8.87 mL 17.74 mL
5 mM 0.35 mL 1.77 mL 3.55 mL
10 mM 0.18 mL 0.89 mL 1.77 mL
50 mM 0.04 mL 0.18 mL 0.35 mL

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参考文献 for cis-22a

参考文献是支持产品生物活性的出版物。

Cunha et al (2019) Photoswitchable inhibitor of the calcium channel TRPV6. ACS Med.Chem.Lett. 10 1341 PMID: 31531207

Simonin et al (2015) Optimization of TRPV6 calcium channel inhibitors using a 3D ligand-based virtual screening method. Angew.Chem.Int.Ed.Engl. 54 14748 PMID: 26457814

If you know of a relevant reference for cis-22a, please let us know.

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关键词: cis-22a, cis-22a supplier, cis22a, selective, TRPV6, inhibitors, inhibitor, inhibits, transient, receptor, potential, vanilloid, 6, TRPV, 7118, Tocris Bioscience

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