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说明： Potent NMDA agonist; also group II mGluR agonist
化学名： (±)-1-Aminocyclopentane-cis-1,3-dicarboxylic acid
生物活性 for cis-ACPD
cis-ACPD is a 1:1 mixture of (1R,3R)- and (1S,3S)-ACPD. Potent NMDA receptor agonist and selective group II mGluR agonist (EC50 values are 13, 50, >300 and >300 μM at mGluR2, mGluR4, mGluR1 and mGluR5 respectively). Exhibits proconvulsant activity in vivo.
(±)-trans-ACPD and (1S,3R)-ACPD also available.
技术数据 for cis-ACPD
| 分子量 | 173.17 |
| 公式 | C7H11NO4 |
| 储存 | Store at RT |
| CAS Number | 477331-06-9 |
| PubChem ID | 16760136 |
| InChI Key | DXLSPTHQGVGVTN-ATXZCBKLSA-N |
| Smiles | [H][C@@]1(CC[C@](N)(C1)C(O)=O)C(O)=O.[H][C@]1(CC[C@@](N)(C1)C(O)=O)C(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for cis-ACPD
参考文献 for cis-ACPD
参考文献是支持产品生物活性的出版物。
Conti et al (2002) Synthesis and pharmacology of 3-hydroxy-Δ2-isoxazoline-cyclopentane analogues of glutamic acid. Farmaco 57 889 PMID: 12484537
Schoepp et al (1991) In vitro and in vivo pharmacology of trans- and cis-(±)-1-amino-1,3-cyclopentanedicarboxylic acid: Dissociation of metabotropic and ionotropic excitatory amino acid receptor effects. J.Neurochem. 56 1789 PMID: 1849553
Sunter et al (1991) Actions of the four isomers of 1-aminocyclopentane-1,3-dicarboxylate (ACPD) in the hemisected spinal cord of the neonatal rat. Br.J.Pharmacol. 104 337P
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关键词: cis-ACPD, cis-ACPD supplier, Potent, NMDA, agonists, group, II, mGluR, Selective, potent, Glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, mGlur, Group, mGlu2, mGlu3, mGluR2, mGluR3, Metabotropic, (Metabotropic), 0186, Tocris Bioscience
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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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