cis MZ 1 | Active Degraders | Tocris Bioscience

cis MZ 1

Pricing Availability   Qty
说明: Negative Control for MZ 1 (Cat. No. 6154)
化学名: (2S,4S)-1-((S)-2-(tert-butyl)-17-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,16-dioxo-6,9,12-trioxa-3,15-diazaheptadecanoyl)- 4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
纯度: ≥98% (HPLC)
说明书
引用文献 (1)
评论
文献 (2)

生物活性 for cis MZ 1

cis MZ 1 is a negative Control for MZ1 (Cat.No. 6154). Exhibits no significant VHL binding affinity.

许可信息

Sold under licence from the University of Dundee

External Portal Information for cis MZ 1

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of MZ 1 is reviewed on the chemical probes website.

技术数据 for cis MZ 1

分子量 1002.64
公式 C49H60ClN9O8S2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1797406-72-4
PubChem ID 124201820
InChI Key PTAMRJLIOCHJMQ-HADAFJFFSA-N
Smiles CC1=C(C2=C(N3C(C)=NN=C3[C@@H](N=C2C4=CC=C(C=C4)Cl)CC(NCCOCCOCCOCC(N[C@@H](C(C)(C)C)C(N5C[C@H](C[C@H]5C(NCC6=CC=C(C7=C(N=CS7)C)C=C6)=O)O)=O)=O)=O)S1)C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for cis MZ 1

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 100.26 100
ethanol 100.26 100

制备储备液 for cis MZ 1

以下数据基于产品分子量 1002.64。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1 mL 4.99 mL 9.97 mL
5 mM 0.2 mL 1 mL 1.99 mL
10 mM 0.1 mL 0.5 mL 1 mL
50 mM 0.02 mL 0.1 mL 0.2 mL

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产品说明书 for cis MZ 1

分析证书/产品说明书
选择另一批次:

参考文献 for cis MZ 1

参考文献是支持产品生物活性的出版物。

Zengerle et al (2015) Selective small molecule induced degradation of the BET bromodomain protein BRD4. ACS.Chem.Biol. 10 1770 PMID: 26035625


If you know of a relevant reference for cis MZ 1, please let us know.

关键词: cis MZ 1, cis MZ 1 supplier, cis, MZ1, PROTAC, protacs, Proteolysis, targeted, chimeras, Bromodomain, BRD2, BRD3, BRD4, BET, proteins, JQ1, VHL, E3, ubiquitin, ligase, HIF-alpha, HIF-a, HIF-α, degraders, negative, controls, Bromodomains, Negative, Controls, 6155, Tocris Bioscience

1 篇 cis MZ 1 的引用文献

引用文献是使用了 Tocris 产品的出版物。 cis MZ 1 的部分引用包括:

Noblejas-Lopez et al (2019) Activity of BET-proteolysis targeting chimeric (PROTAC) compounds in triple negative breast cancer. J Exp Clin Cancer Res 38 383 PMID: 31470872


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该领域的文献

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*请注意,Tocris 仅会向正规科研企业/机构地址发送文献。


TPD and Induced Proximity Research Product Guide

TPD and Induced Proximity Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:

  • Active Degraders
  • TAG Degradation Platform
  • Degrader Building Blocks
  • Assays for Protein Degradation
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Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia