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Submit Reviewcis MZ 1 is a negative Control for MZ1 (Cat.No. 6154). Exhibits no significant VHL binding affinity.
Sold under licence from the University of Dundee
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of MZ 1 is reviewed on the chemical probes website.
分子量 | 1002.64 |
公式 | C49H60ClN9O8S2 |
储存 | Store at -20°C |
纯度 | ≥98% (HPLC) |
CAS Number | 1797406-72-4 |
PubChem ID | 124201820 |
InChI Key | PTAMRJLIOCHJMQ-HADAFJFFSA-N |
Smiles | CC1=C(C2=C(N3C(C)=NN=C3[C@@H](N=C2C4=CC=C(C=C4)Cl)CC(NCCOCCOCCOCC(N[C@@H](C(C)(C)C)C(N5C[C@H](C[C@H]5C(NCC6=CC=C(C7=C(N=CS7)C)C=C6)=O)O)=O)=O)=O)S1)C |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
---|---|---|---|
溶解性 | |||
DMSO | 100.26 | 100 | |
ethanol | 100.26 | 100 |
以下数据基于产品分子量 1002.64。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1 mL | 4.99 mL | 9.97 mL |
5 mM | 0.2 mL | 1 mL | 1.99 mL |
10 mM | 0.1 mL | 0.5 mL | 1 mL |
50 mM | 0.02 mL | 0.1 mL | 0.2 mL |
参考文献是支持产品生物活性的出版物。
Zengerle et al (2015) Selective small molecule induced degradation of the BET bromodomain protein BRD4. ACS.Chem.Biol. 10 1770 PMID: 26035625
If you know of a relevant reference for cis MZ 1, please let us know.
关键词: cis MZ 1, cis MZ 1 supplier, cis, MZ1, PROTAC, protacs, Proteolysis, targeted, chimeras, Bromodomain, BRD2, BRD3, BRD4, BET, proteins, JQ1, VHL, E3, ubiquitin, ligase, HIF-alpha, HIF-a, HIF-α, degraders, negative, controls, Bromodomains, Negative, Controls, 6155, Tocris Bioscience
引用文献是使用了 Tocris 产品的出版物。 cis MZ 1 的部分引用包括:
Noblejas-Lopez et al (2019) Activity of BET-proteolysis targeting chimeric (PROTAC) compounds in triple negative breast cancer. J Exp Clin Cancer Res 38 383 PMID: 31470872
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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意,Tocris 仅会向正规科研企业/机构地址发送文献。
This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:
Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia