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说明： NAADP antagonist; inhibits Ca2+ release
化学名： (1S,3S)-1-[3-[[4-(2-Fluorophenyl)piperazin-1-yl]methyl]-4-methoxyphenyl]-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid
纯度： ≥97% (HPLC)
生物活性 for cis-Ned 19
cis-Ned 19 is an irreversible nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist; inhibits Ca2+ release (IC50 = 800 nM) and [32P]NAADP binding (IC50 = 15 μM). Stereoisomer of trans-Ned 19. Fluorescently labels NAADP receptors in intact cells (excitation 351 and 365 nm using an ultraviolet Argon laser).
Isomer of trans-Ned 19.
Optical Data for cis-Ned 19
| λabs | 368 nm |
|---|---|
| λem | 425 nm |
| Closest Laser line | 355 nm |
| Cell Permeable | Yes |
| Application | Confocal Microscopy |
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技术数据 for cis-Ned 19
| 分子量 | 514.59 |
| 公式 | C30H31FN4O3 |
| 储存 | Store at -20°C |
| 纯度 | ≥97% (HPLC) |
| CAS Number | 1137264-00-6 |
| PubChem ID | 1427626 |
| InChI Key | FUHCEERDBRGPQZ-LSYYVWMOSA-N |
| Smiles | FC1=CC=CC=C1N(CC6)CCN6CC2=C[C@@]([C@H]3C4=C(C(C=CC=C5)=C5N4)C[C@@H]([C@@](O)=O)N3)=CC=C2OC |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for cis-Ned 19
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 51.46 | 100 |
制备储备液 for cis-Ned 19
以下数据基于产品分子量 514.59。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.94 mL | 9.72 mL | 19.43 mL |
| 5 mM | 0.39 mL | 1.94 mL | 3.89 mL |
| 10 mM | 0.19 mL | 0.97 mL | 1.94 mL |
| 50 mM | 0.04 mL | 0.19 mL | 0.39 mL |
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产品说明书 for cis-Ned 19
参考文献 for cis-Ned 19
参考文献是支持产品生物活性的出版物。
Naylor et al (2009) Identification of a chemical probe for NAADP by virtual screening. Nat.Chem.Biol. 5 220 PMID: 19234453
If you know of a relevant reference for cis-Ned 19, please let us know.
关键词: cis-Ned 19, cis-Ned 19 supplier, cis-Ned19, NAADP, nicotinic, acid, adenine, dinucleotide, phosphate, antagonists, calcium, signaling, signalling, inhibitors, inhibits, fluorescent, probes, ned19, General, Calcium, Signaling, Agents, 3953, Tocris Bioscience
2 篇 cis-Ned 19 的引用文献
引用文献是使用了 Tocris 产品的出版物。 cis-Ned 19 的部分引用包括：
Favia et al (2014) VEGF-induced neoangiogenesis is mediated by NAADP and two-pore channel-2-dependent Ca2+ signaling. Proc Natl Acad Sci U S A 111 E4706 PMID: 25331892
Gerasimenko et al (2015) Both RyRs and TPCs are required for NAADP-induced intracellular Ca2+ release. Sci Rep 58 237 PMID: 26100948
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