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Discontinued Product
3953 has been discontinued.
View all General Calcium Signaling Agents products.
说明： NAADP antagonist; inhibits Ca2+ release
化学名： (1S,3S)-1-[3-[[4-(2-Fluorophenyl)piperazin-1-yl]methyl]-4-methoxyphenyl]-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid
纯度： ≥97% (HPLC)
生物活性 for cis-Ned 19
cis-Ned 19 is an irreversible nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist; inhibits Ca2+ release (IC50 = 800 nM) and [32P]NAADP binding (IC50 = 15 μM). Stereoisomer of trans-Ned 19. Fluorescently labels NAADP receptors in intact cells (excitation 351 and 365 nm using an ultraviolet Argon laser).
Isomer of trans-Ned 19.
Optical Data for cis-Ned 19
| λabs | 368 nm |
|---|---|
| λem | 425 nm |
| Closest Laser line | 355 nm |
| Cell Permeable | Yes |
| Application | Confocal Microscopy |
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技术数据 for cis-Ned 19
| 分子量 | 514.59 |
| 公式 | C30H31FN4O3 |
| 储存 | Store at -20°C |
| 纯度 | ≥97% (HPLC) |
| CAS Number | 1137264-00-6 |
| PubChem ID | 1427626 |
| InChI Key | FUHCEERDBRGPQZ-LSYYVWMOSA-N |
| Smiles | FC1=CC=CC=C1N(CC6)CCN6CC2=C[C@@]([C@H]3C4=C(C(C=CC=C5)=C5N4)C[C@@H]([C@@](O)=O)N3)=CC=C2OC |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for cis-Ned 19
参考文献 for cis-Ned 19
参考文献是支持产品生物活性的出版物。
Naylor et al (2009) Identification of a chemical probe for NAADP by virtual screening. Nat.Chem.Biol. 5 220 PMID: 19234453
关键词: cis-Ned 19, cis-Ned 19 supplier, cis-Ned19, NAADP, nicotinic, acid, adenine, dinucleotide, phosphate, antagonists, calcium, signaling, signalling, inhibitors, inhibits, fluorescent, probes, ned19, General, Calcium, Signaling, Agents, 3953, Tocris Bioscience
2 篇 cis-Ned 19 的引用文献
引用文献是使用了 Tocris 产品的出版物。 cis-Ned 19 的部分引用包括：
Gerasimenko et al (2015) Both RyRs and TPCs are required for NAADP-induced intracellular Ca2+ release. Sci Rep 58 237 PMID: 26100948
Favia et al (2014) VEGF-induced neoangiogenesis is mediated by NAADP and two-pore channel-2-dependent Ca2+ signaling. Proc Natl Acad Sci U S A 111 E4706 PMID: 25331892
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