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Submit ReviewCK 869
说明： Arp2/3 inhibitor; inhibits actin polymerization
别名： CK-0157869
化学名： 2-(3-Bromophenyl)-3-(2,4-dimethoxyphenyl)-4-thiazolidinone
纯度： ≥98% (HPLC)
生物活性 for CK 869
CK 869 is an inhibitor of human and bovine actin-related protein 2/3 (Arp2/3) complex. Inhibits actin polymerization (IC50= 11 μM). Does not inhibit budding or fission yeast Arp2/3 complexes.
技术数据 for CK 869
| 分子量 | 394.28 |
| 公式 | C17H16BrNO3S |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 388592-44-7 |
| PubChem ID | 3574452 |
| InChI Key | MVWNPZYLNLATCH-UHFFFAOYSA-N |
| Smiles | O=C1N(C3=CC=C(OC)C=C3OC)C(C2=CC=CC(Br)=C2)SC1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for CK 869
参考文献 for CK 869
参考文献是支持产品生物活性的出版物。
Hetrick et al (2013) Small molecules CK-666 and CK-869 inhibit actin-related protein 2/3 complex by blocking an activating conformational change. Chem Biol. 20 701 PMID: 23623350
Nolen et al (2009) Characterization of two classes of small molecule inhibitors of Arp2/3 complex. Nature 460 1031 PMID: 19648907
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关键词: CK 869, CK 869 supplier, CK869, CK-0157869, actin-related, protein, Arp2/3, Arp23, complex, actin, polymerization, inhibitors, inhibits, Actin, 4984, Tocris Bioscience
2 篇 CK 869 的引用文献
引用文献是使用了 Tocris 产品的出版物。 CK 869 的部分引用包括：
Bharadwaj (2017) αV-class integrins exert dual roles on α5β1 integrins to strengthen adhesion to fibronectin. Nat Commun 8 14348 PMID: 28128308
Yamagashi et al (2018) Use of CK-548 and CK-869 as Arp2/3 complex inhibitors directly suppresses microtubule assembly both in vitro and in vivo. Biochem.Biophys.Res.Commun. 496 834 PMID: 29395083
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