Clemizole hydrochloride

Name: Clemizole hydrochloride
Brand: Tocris Bioscience
SKU: 5371

Cat. No. 5371 3 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

This product has been withdrawn from sale and is superseded by AC 1903 (Cat. No. 6766)

说明： TRPC5 blocker; also H₁ antagonist

化学名： 1-[(4-Chlorophenyl)methyl]-2-(1-pyrrolidinylmethyl)-1H-benzimidazole hydrochloride

纯度： ≥99% (HPLC)

说明书

引用文献 (3)

生物活性技术数据说明书参考文献

生物活性 for Clemizole hydrochloride

TRPC5 channel blocker (IC₅₀ values are 1.1, 6.4, 9.1, 11.3 and 26.5 μM for TRPC5, TRPC4, TRPC3, TRPC6 and TRPC7 respectively). Exhibits minimal effect on TRPM3, TRPM8 and TRPV1-4 channels. Also histamine H₁ receptor antagonist and anticonvulsant in zebrafish Dravet syndrome model.

技术数据 for Clemizole hydrochloride

分子量	362.3
公式	C₁₉H₂₀ClN₃. HCl
储存	Desiccate at RT
纯度	≥99% (HPLC)
CAS Number	1163-36-6
PubChem ID	14412
InChI Key	DNFMJYXRIMLMBZ-UHFFFAOYSA-N
Smiles	ClC(C=C4)=CC=C4CN2C(CN3CCCC3)=NC1=CC=CC=C12.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Clemizole hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Clemizole hydrochloride

参考文献是支持产品生物活性的出版物。

Aguilar et al (1986) Pharmacological investigation into the effects of histamine and histamine analogues on guinea-pig and rat colon in vitro. Br.J.Pharmacol. 88 501 PMID: 3742147

Richter et al (2014) Clemizole hydrochloride is a novel and potent inhibitor of transient receptor potential channel TRPC5. Mol.Pharm. 86 514 PMID: 25140002

Baraban et al (2013) Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment. Nat.Commun. 4 2410 PMID: 24002024

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关键词: Clemizole hydrochloride, Clemizole hydrochloride supplier, transient, potential, channels, TRPC5, histamine, receptors, blockers, antagonists, TRPC, Histamine, H1, Receptors, 5371, Tocris Bioscience