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Submit ReviewClocinnamox mesylate
Discontinued Product
0898 has been discontinued.
说明： Irreversible μ antagonist
别名： NIH 10443,C-CAM
化学名： 14β-(p-Chlorocinnamoylamino)-7,8-dihydro-N-cyclopropylmethylmorphinone mesylate
纯度： ≥98% (HPLC)
生物活性 for Clocinnamox mesylate
Clocinnamox mesylate is a systemically active, irreversible μ-opioid receptor antagonist (apparent Ki values are 0.7, 1.9 and 5.7 nM for mouse μ, δ and κ receptors respectively).
技术数据 for Clocinnamox mesylate
| 分子量 | 601.11 |
| 公式 | C29H29ClN2O4.CH3SO3H |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 117332-69-1 |
| PubChem ID | 90479744 |
| InChI Key | XAXNKAGAUFXFDO-JVJDXIHNSA-N |
| Smiles | C[S](O)(=O)=O.[H][C@@]12OC3=C4C(C[C@@]5([H])N(CC6CC6)CC[C@@]14[C@]5(CCC2=O)NC(=O)C=CC1=CC=C(Cl)C=C1)=CC=C3O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Clocinnamox mesylate
参考文献 for Clocinnamox mesylate
参考文献是支持产品生物活性的出版物。
Aceto et al (1989) Very long-acting narcotic antagonists. The 14β-p-substituted cinnamoylaminomorphinones and their partial mu agonist codeinone relatives. Arzneimittelforschung 39 570 PMID: 2547389
Burke et al (1994) Irreversible opioid antagonist effects of clocinnamox on opioid analgesia and mu receptor binding in mice. J.Pharmacol.Exp.Ther. 271 715 PMID: 7965787
Zernig et al (1996) Mechanism of clocinnamox blockade of opioid receptors: evidence from in vitro and ex vivo binding and behavioural assays. J.Pharmacol.Exp.Ther. 279 23 PMID: 8858971
Broadbear et al (2000) Methocinnamox is a potent, long-lasting, and selective antagonist of morphine-mediated antinociception in the mouse: comparison with clocinnamox, β-funaltrexamine, and β-chlornaltrexamine. J.Pharmacol.Exp.Ther. 294 933 PMID: 10945843
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关键词: Clocinnamox mesylate, Clocinnamox mesylate supplier, irreversible, mu-opioids, m-opioids, μ-opioids, receptors, antagonists, NIH, 10443, C-CAM, Mu, Opioid, Receptors, 0898, Tocris Bioscience
1 篇 Clocinnamox mesylate 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Clocinnamox mesylate 的部分引用包括：
Sirohi et al (2008) The analgesic efficacy of fentanyl: relationship to tolerance and mu-opioid receptor regulation. Pharmacol Biochem Behav 91 115 PMID: 18640146
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