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Submit ReviewClotrimazole
说明： Cytochrome P450 inhibitor; antifungal
别名： CLT
化学名： 1-(2-Chloro-α,α-diphenylbenzyl)imidazole
纯度： ≥99% (HPLC)
生物活性 for Clotrimazole
Clotrimazole is an imidazole antimycotic and cytochrome P450 inhibitor. Inhibits Ca2+-activated K+ current (IC50 = 3 μM) and L-type Ca2+ current; increases the firing rate of action potentials. Exhibits antiproliferative activity in vitro and in vivo. Also an inverse agonist of the human constitutive androstane receptor (hCAR).
化合物库 for Clotrimazole
Clotrimazole is also offered as part of the Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。
技术数据 for Clotrimazole
| 分子量 | 344.84 |
| 公式 | C22H17ClN2 |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 23593-75-1 |
| PubChem ID | 2812 |
| InChI Key | VNFPBHJOKIVQEB-UHFFFAOYSA-N |
| Smiles | ClC1=CC=CC=C1C(C3=CC=CC=C3)(C4=CC=CC=C4)N2C=CN=C2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Clotrimazole
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 25.86 | 75 | |
| ethanol | 34.48 | 100 |
制备储备液 for Clotrimazole
以下数据基于产品分子量 344.84。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.9 mL | 14.5 mL | 29 mL |
| 5 mM | 0.58 mL | 2.9 mL | 5.8 mL |
| 10 mM | 0.29 mL | 1.45 mL | 2.9 mL |
| 50 mM | 0.06 mL | 0.29 mL | 0.58 mL |
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产品说明书 for Clotrimazole
参考文献 for Clotrimazole
参考文献是支持产品生物活性的出版物。
Snajdrova et al (1998) Clomitrazole, an antimycotic drug, inhibits the sarcoplasmic reticulum calcium pump and contractile function in heart muscle. J.Biol.Chem. 273 28032 PMID: 9774419
Wu et al (1999) Inhibition of Ca2+-activated K+ current by clotrimazole in rat anterior pituitary GH3 cells. Neuropharmacology 38 979 PMID: 10428416
Thomas et al (1999) The antifungal antibiotic clotrimazole potently inhibits L-type calcium current in guinea-pig ventricular myocytes. Br.J.Pharmacol. 126 1531 PMID: 10323582
Lempiainen et al (2005) Antagonist- and inverse agonist-driven interactions of the vitamin D receptor and the constitutive androstane receptor with corepressor protein. Mol.Endocrinol. 19 2258 PMID: 15905360
If you know of a relevant reference for Clotrimazole, please let us know.
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关键词: Clotrimazole, Clotrimazole supplier, inhibits, calcium-activated, potassium, channels, Ca2+-activated, K+, inhibitors, antifungal, antimycotic, cytochrome, P450, oxidase, CLT, Cytochrome, Constitutive, Androstane, Receptor, Antifungals, 4096, Tocris Bioscience
3 篇 Clotrimazole 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Clotrimazole 的部分引用包括：
Rossen et al (2021) Pseudomonas aeruginosa-induced nociceptor activation increases susceptibility to infection. PLoS Pathog 17 e1009557 PMID: 33956874
Anne-Amandine et al (2021) TREK channel activation suppresses migraine pain phenotype. iScience 24 102961 PMID: 34458705
Mark M et al (2021) Neuronal complexity is attenuated in preclinical models of migraine and restored by HDAC6 inhibition. Elife 10 PMID: 33856345
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