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CLP 257

Cat. No. 5242 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Selective KCC2 activator
化学名： (5Z)-5-[(4-Fluoro-2-hydroxyphenyl)methylene]-2-(tetrahydro-1-(2H)-pyridazinyl)-4(5H)-thiazolone
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for CLP 257

CLP 257 is a selective KCC2 K+-Cl- cotransporter activator (EC50 = 616 nM). Exhibits selectivity for KCC2 over other KCC family members, NKCC1 and GABAA receptors, as well as 55 other receptors. Enhances Cl- transport and increases KCC2 plasma membrane expression in spinal slices with reduced KCC2 function. Alleviates hypersensitivity in rats with peripheral nerve injury.

技术数据 for CLP 257

分子量 307.34
公式 C14H14FN3O2S
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 1181081-71-9
PubChem ID 44188931
InChI Key SKCADXVKQRCWTR-GHXNOFRVSA-N
Smiles OC1=C(/C=C2/C(N=C(N3CCCCN3)S2)=O)C=CC(F)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for CLP 257

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 30.73 100

制备储备液 for CLP 257

以下数据基于产品分子量 307.34。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.25 mL 16.27 mL 32.54 mL
5 mM 0.65 mL 3.25 mL 6.51 mL
10 mM 0.33 mL 1.63 mL 3.25 mL
50 mM 0.07 mL 0.33 mL 0.65 mL

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参考文献 for CLP 257

参考文献是支持产品生物活性的出版物。

Gagnon et al (2013) Chloride extrusion enhancers as novel therapeutics for neurological diseases. Nat.Med. 19 1524 PMID: 24097188

If you know of a relevant reference for CLP 257, please let us know.

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关键词: CLP 257, CLP 257 supplier, CLP257, Selective, KCC2, K+-Cl-, cotransporters, activators, neuropathic, pain, K+/Cl-, Cotransporter, 2, 5242, Tocris Bioscience

1 篇 CLP 257 的引用文献

引用文献是使用了 Tocris 产品的出版物。 CLP 257 的部分引用包括：

Ferando et al (2016) Diminished KCC2 confounds synapse specificity of LTP during senescence. Nat Neurosci 19 1197 PMID: 27500406

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