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CMA

Cat. No. 6677 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Murine-selective STING agonist
化学名： 9-Oxo-10(9H)-acridineacetic acid
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for CMA

CMA is a STING agonist; murine-selective (Kd = 3.5 μM). Triggers type I IFN response in murine macrophages, with no effect on human STING signaling.

化合物库 for CMA

CMA is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for CMA

分子量 253.25
公式 C15H11NO3
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 38609-97-1
PubChem ID 38072
InChI Key UOMKBIIXHQIERR-UHFFFAOYSA-N
Smiles OC(CN1C2=CC=CC=C2C(C3=C1C=CC=C3)=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for CMA

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 25.32 100

制备储备液 for CMA

以下数据基于产品分子量 253.25。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.95 mL 19.74 mL 39.49 mL
5 mM 0.79 mL 3.95 mL 7.9 mL
10 mM 0.39 mL 1.97 mL 3.95 mL
50 mM 0.08 mL 0.39 mL 0.79 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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参考文献 for CMA

参考文献是支持产品生物活性的出版物。

Haag et al (2018) Targeting STING with covalent small-molecule inhibitors. Nature 559 269 PMID: 29973723

Cavlar et al (2013) Species-specific detection of the antiviral small-molecule compound CMA by STING. EMBO J. 32 1440 PMID: 23604073

Zhang et al (2015) Rat and human STINGs profile similarly towards anticancer/antiviral compounds. Sci. Rep. 5 18035 PMID: 26669264

If you know of a relevant reference for CMA, please let us know.

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关键词: CMA, CMA supplier, Murine-selective, STING, agonists, agonism, STING-Dependent, Signaling, 6677, Tocris Bioscience

1 篇 CMA 的引用文献

引用文献是使用了 Tocris 产品的出版物。 CMA 的部分引用包括：

Jie et al (2023) Discovery of an inhibitor of DNA-driven inflammation that preferentially targets the AIM2 inflammasome. iScience 26 106758 PMID: 37216118

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