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Co 102862

Cat. No. 2642 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

2642 has been discontinued.

View all Voltage-gated Sodium (Na<sub>V</sub>) Channels products.
说明： State-dependent of voltage-gated sodium channels
别名： V102862
化学名： 2-[[4-(4-Fluorophenoxy)phenyl]methylene]hydrazinecarboxamide
纯度： ≥99% (HPLC)
说明书
引用文献
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生物活性 技术数据 说明书 参考文献

生物活性 for Co 102862

Co 102862 is a broad spectrum, state-dependent blocker of voltage-gated sodium channels. Displays ~ 80-fold higher affinity for inactivated Na+ channels compared to channels in the resting state. Anticonvulsant; displays activity in rodent models of tonic/clonic and partial-complex seizures.

技术数据 for Co 102862

分子量 273.26
公式 C14H12FN3O2
储存 Store at RT
纯度 ≥99% (HPLC)
CAS Number 181144-66-1
PubChem ID 9816959
InChI Key MHUUDVZSPFRUSK-RQZCQDPDSA-N
Smiles NC(=O)N\N=C\C1=CC=C(OC2=CC=C(F)C=C2)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for Co 102862

参考文献是支持产品生物活性的出版物。

Ilyin et al (2005) V102862 (Co 102862): a potent, broad-spectrum state-dependent blocker of mammalian voltage-gated sodium channels. Br.J.Pharmacol. 144 801 PMID: 15778702

Ilyin et al (2006) Pharmacology of 2-[4-(4-chloro-2-fluorophenoxy)phenyl]-pyrimidine-4-carboxamide: a potent, broad-spectrum state-dependent sodium channel blocker for treating pain states. J.Pharmacol.Exp.Ther. 318 1083 PMID: 16728593

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关键词: Co 102862, Co 102862 supplier, State-dependent, Na+, channel, blockers, anticonvulsant, Sodium, NaV, Channels, voltage-gated, voltage-dependent, Co102862, V102862, Voltage-gated, 2642, Tocris Bioscience

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