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Submit ReviewCocaine hydrochloride
说明： Inhibitor of monoamine transporters
化学名： 3β-Hydroxy-1αH,5αH-tropane-2β-carboxylic acid methyl ester benzoate hydrochloride
纯度： ≥99% (HPLC)
生物活性 for Cocaine hydrochloride
Competitive inhibitor of monoamine neurotransmitter transporters. Inhibits dopamine (DAT), serotonin (SERT) and noradrenalin (NET) transporters with Ki values are 267, 392 and 872 nM respectively. Psychostimulant.
技术数据 for Cocaine hydrochloride
| 分子量 | 339.81 |
| 公式 | C17H21NO4.HCl |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 53-21-4 |
| PubChem ID | 656832 |
| InChI Key | PIQVDUKEQYOJNR-VZXSFKIWSA-N |
| Smiles | O=C(C3=CC=CC=C3)O[C@@H]2[C@H]([C@](OC)=O)[C@@]1([H])CC[C@](C2)([H])N1C.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Cocaine hydrochloride
参考文献 for Cocaine hydrochloride
参考文献是支持产品生物活性的出版物。
Fleckenstein et al (2000) Differential effects of stimulants on monoaminergic transporters: pharmacological consequences and implications for neurotoxicity. Eur.J.Pharmacol. 406 1 PMID: 11011026
Torres et al (2003) Plasma membrane monoamine transporters: structure, regulation and function. Nat.Rev.Neurosci. 4 13 PMID: 12511858
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关键词: Cocaine hydrochloride, Cocaine hydrochloride supplier, inhibitors, inhibits, monoamine, transporters, noradrenalin, noradrenaline, NET, adrenergic, neurotransmitter, DAT, dopamine, serotonin, SERT, 5-HT, reuptake, 5-Hydroxytryptamine, Dopamine, Transporters, Adrenergic, 2833, Tocris Bioscience
3 篇 Cocaine hydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Cocaine hydrochloride 的部分引用包括：
Rennekamp et al (2016) σ1 receptor ligands control a switch between passive and active threat responses. Nat Chem Biol 12 552 PMID: 27239788
Ferraro et al (2012) A novel mechanism of cocaine to enhance DA d2-like receptor mediated neurochemical and behavioral effects. An in vivo and in vitro study. Neuropsychopharmacology 37 1856 PMID: 22453136
Luu and Malenka (2008) Spike timing-dependent long-term potentiation in ventral tegmental area DA cells requires PKC. J Neurophysiol 100 533 PMID: 18450581
Cocaine hydrochloride 的评论
平均评分: 5 (Based on 1 Review.)
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Chronic restraint stress during withdrawal increases vulnerability to drug priming-induced cocaine seeking.
By
Kevin Ball on 01/28/2019
分析类型： In Vivo
种属： Rat
We tested the effect of chronic restraint stress on cocaine seeking in rats using both extinction- and abstinence-based animal relapse models. Rats were trained to press a lever for I.V. cocaine infusions (0.50 mg/kg/infusion) paired with a discrete tone+light cue in daily 3-h sessions. A main finding was that a history of chronic restraint stress was associated with increased cocaine priming-induced drug seeking.
该领域的文献
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*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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