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Submit ReviewConantokin-R
说明： Potent non-competitive NMDA antagonist
生物活性 for Conantokin-R
Potent, non-competitive NMDA receptor antagonist (IC50 = 93 nM) that has been suggested to have GluN2 (formally NR2) subunit selectivity. Inhibits inward currents evoked by NMDA in central nervous system neurons (IC50 = 350 nM) and exhibits broad anticonvulsant and antiparkinsonian activity in vivo at doses devoid of behavioral toxicity.
Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.
许可信息
Sold under license from University of Utah
技术数据 for Conantokin-R
| 分子量 | 3098.4 |
| 公式 | C127H201N35O49S3 |
| 序列 |
GEXXVAKMAAXLARXNIAKGCKVNCYP (Modifications: X = Gla, Disulfide bridge between 21 - 25) |
| 储存 | Store at -20°C |
| CAS Number | 202925-60-8 |
| PubChem ID | 90488802 |
| InChI Key | MJQQZSPLVNQFRB-HHXUSTKESA-N |
| Smiles | [H]NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C(O)=O)C(O)=O)C(=O)N[C@@H](CC(C(O)=O)C(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C(O)=O)C(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C(O)=O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC1=O)C(C)C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N1CCC[C@H]1C(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Conantokin-R
参考文献 for Conantokin-R
参考文献是支持产品生物活性的出版物。
Blandl et al (2000) Structure-function relationships of the NMDA-receptor antagonist peptide, conantokin-R. FEBS Lett. 470 139 PMID: 10734223
Klein et al (2001) The amino acid residue at sequence position 5 in the conantokin peptides partially governs subunit-selective antagonism of recombinant N-MthD.-aspartate receptors. J.Biol.Chem. 276 26860 PMID: 11335724
White et al (2000) In vitro and in vivo characterization of conantokin-R, a selective NMDA receptor antagonist isolated from the venom of the fish-hunting snail Conus radiatus. J.Pharmacol.Expr.Ther. 292 425
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关键词: Conantokin-R, Conantokin-R supplier, Potent, non-competitive, NMDA, receptor, antagonists, Glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, venoms, GluN2, 3125, Tocris Bioscience
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