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说明： Selective CB2 receptor inverse agonist
化学名： N-(Adamant-1-yl)-4-oxo-1-pentyl-6-phenyl-1,4-dihydroquinoline-3-carboxamide
纯度： ≥99% (HPLC)
生物活性 for COR 170
COR 170 is a selective inverse agonist of CB2 receptors (Ki values are 3.8 and >10,000 nM for CB2 and CB1, respectively).
技术数据 for COR 170
| 分子量 | 468.63 |
| 公式 | C31H36N2O2 |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 1048039-15-1 |
| PubChem ID | 25033736 |
| InChI Key | MSJISJDTJJYBFT-UHFFFAOYSA-N |
| Smiles | O=C(C4=CN(CCCCC)C5=C(C=C(C6=CC=CC=C6)C=C5)C4=O)NC12CC(C3)CC(CC3C2)C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for COR 170
参考文献 for COR 170
参考文献是支持产品生物活性的出版物。
Pasquini et al (2008) Investigations on the 4-quinolone-3-carboxylic acid motif. 2. Synthesis and structure-activity relationship of potent and selective cannabinoid-2 receptor agonists endowed with analgesic activity in vivo. J.Med.Chem. 51 5075 PMID: 18680276
Contartese et al (2012) A novel CB2 agonist, COR167, potently protects rat brain cortical slices against OGD and reperfusion injury. Pharmacol.Res. 66 555 PMID: 23036353
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关键词: COR 170, COR 170 supplier, COR170, CB2, receptors, C2BR, inverse, agonists, selective, cannabinoids, Receptors, 4756, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Cannabinoid Receptor Ligands Scientific Review
Written by Roger Pertwee, this review discusses compounds which affect the activity of the endocannabinoid system, focusing particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.