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Submit ReviewCortistatin 14
说明： Endogenous neuropeptide; binds sst1 - sst5, ghrelin receptor and MRGPRX2
纯度： ≥95% (HPLC)
生物活性 for Cortistatin 14
Cortistatin 14 is an endogenous neuropeptide, mainly expressed in the cortex and hippocampus, that has structural and functional similarities to somatostatin-14. Cortistatin 14 displays potency at all somatostatin receptors (sst1 - sst5) and prevents somatostatin-14 binding (IC50 values are 0.09, 0.2, 0.3, 0.3 and 5 nM at sst2, sst4, sst3, sst5 and sst1 receptors, respectively). Also a potent MRGPRX2 agonist (EC50 = 25 nM in HEK293 cells) and binds to the growth hormone secretagog receptor (GHS-R1a). Exhibits neuronal depressant and sleep-modulating properties in vivo.
技术数据 for Cortistatin 14
| 分子量 | 1721.03 |
| 公式 | C81H113N19O19S2 |
| 序列 |
PCKNFFWKTFSSCK (Modifications: Disulfide bridge: 2-13) |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 193829-96-8 |
| PubChem ID | 16133803 |
| InChI Key | DDRPLNQJNRBRNY-WYYADCIBSA-N |
| Smiles | [H]N1CCC[C@H]1C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Cortistatin 14
| 溶解性 | Soluble to 0.70 mg/ml in water |
产品说明书 for Cortistatin 14
参考文献 for Cortistatin 14
参考文献是支持产品生物活性的出版物。
Deghenghi et al (2001) Cortistatin, but not somatostatin, binds to GH secretagogue (GHS) receptors of the human pituitary gland. J.Endocrinol.Invest. 24 RC1 PMID: 11227737
Fukusumi et al (1997) Identification and characterization of a novel human cortisan-like peptide. Biochem.Biophys.Res.Comm. 232 157 PMID: 9125122
Spier and de Lecea (2000) Cortistatin: a member of the somatostatin neuropeptide family with distinct physiological functions. Brain Res. 33 228 PMID: 11011067
Solinski et al (2014) Pharmacology and signaling of MAS-related G protein-coupled receptors. Pharmacol.Rev. 66 570 PMID: 24867890
Robas et al (2003) MrgX2 is a high potency cortistatin receptor expressed in dorsal root ganglion. J.Biol.Chem. 278 44400 PMID: 12915402
If you know of a relevant reference for Cortistatin 14, please let us know.
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关键词: Cortistatin 14, Cortistatin 14 supplier, Endogenous, neuropeptide, binds, sst1, sst2, sst3, sst4, sst5, GHS-R1a, Receptors, Somatostatin, Growth, Hormone, Secretagogue, 1a, Ghrelin, Cortistatin14, neuropeptides, mas-related, g, protein-coupled, receptors, MRGPRX2, Mas-related, G, Protein-Coupled, 3374, Tocris Bioscience
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