Costunolide

Name: Costunolide
Brand: Tocris Bioscience
SKU: 2483

Cat. No. 2483 5 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

2483 has been discontinued.

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说明： Inhibitor of human telomerase activity

化学名： (3aS,6E,10E,11aR)-3a,4,5,8,9,11a-Hexahydro-6,10-dimethyl-3-methylene-cyclodeca[b]furan-2(3H)-one

纯度： ≥97% (HPLC)

说明书

引用文献 (5)

生物活性技术数据说明书参考文献

生物活性 for Costunolide

Costunolide is an inhibitor of human telomerase activity (IC₅₀ = 65 μM in MCF-7 breast cancer cells). Suppresses proliferation and induces apoptosis in a variety of human tumor cell lines. Selectively blocks endothelial cell proliferation induced by VEGF. Inhibits expression of iNOS and IL-1β and disrupts NF-κB activation. Displays anti-inflammatory, antifungal and antiviral properties.

技术数据 for Costunolide

分子量	232.32
公式	C₁₅H₂₀O₂
储存	Store at -20°C
纯度	≥97% (HPLC)
CAS Number	553-21-9
PubChem ID	5281437
InChI Key	HRYLQFBHBWLLLL-AHNJNIBGSA-N
Smiles	C/C1=C\[C@@H](OC([C@]2=C)=O)[C@H]2CC/C(C)=C/CC1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Costunolide

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Costunolide

参考文献是支持产品生物活性的出版物。

Park et al (1996) Syringin 4-O-β-glucoside, a new phenylpropanoid glycoside, and costunolide, a nitric oxide synthase inhibitor, from the stem bark of Magnolia sieboldi. J.Nat.Prod. 59 1128 PMID: 8988596

Jeong et al (2002) Costunolide, a sesquiterpene lactone from Saussurea lappa, inhibits the VEGFR KDR/Flk-1 signaling pathway. Cancer Lett. 187 129 PMID: 12359360

Choi et al (2005) Inhibitory effects of costunolide on the telomerase activity in human breast carcinoma cells. Cancer Lett. 227 153 PMID: 16112418

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