CP 31398 dihydrochloride

Name: CP 31398 dihydrochloride
Brand: Tocris Bioscience
SKU: 3023

Cat. No. 3023 2 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

3023 has been discontinued.

View all p53 products.

说明： p53-stabilizing agent

化学名： N'-[2-[2-(4-Methoxyphenyl)ethenyl]-4-quinazolinyl]-N,N-dimethyl-1,3-propanediamine dihydrochloride

纯度： ≥99% (HPLC)

说明书

引用文献 (2)

文献 (2)

通路 (1)

生物活性技术数据说明书参考文献

生物活性 for CP 31398 dihydrochloride

CP 31398 dihydrochloride is a p53 stabilizing agent. Stabilizes the active conformation of p53 and promotes p53 activity in cancer cell lines with mutant or wild-type p53. Inhibits growth of small human tumor xenografts in vivo.

许可信息

Sold for research purposes under agreement from Pfizer Inc.

技术数据 for CP 31398 dihydrochloride

分子量	435.39
公式	C₂₂H₂₆N₄O.2HCl
储存	Desiccate at RT
纯度	≥99% (HPLC)
CAS Number	1217195-61-3
PubChem ID	56972205
InChI Key	WWIFDJIOGCGSBS-IVKCLRODSA-N
Smiles	COC(C=C3)=CC=C3/C=C/C2=NC1=CC=CC=C1C(NCCCN(C)C)=N2.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for CP 31398 dihydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for CP 31398 dihydrochloride

参考文献是支持产品生物活性的出版物。

Foster et al (1999) Pharmacological rescue of mutant p53 conformation and function. Science 286 2507 PMID: 10617466

Wischhusen et al (2003) CP-31398, a novel p53-stabilizing agent, induces p53-dependent and p53-independent glioma cell death. Oncogene 22 8233 PMID: 14614447

Demma et al (2004) CP-31398 restores DNA-binding activity to mutant p53 in vitro but does not affect p53 homologs p63 and p73. J.Biol.Chem. 279 45887 PMID: 15308639

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关键词: CP 31398 dihydrochloride, CP 31398 dihydrochloride supplier, p53-stabilizing, p53-stabilising, agent, Transcription, Factors, CP31398, dihydrochloride, Pfizer, p53, 3023, Tocris Bioscience

2 篇 CP 31398 dihydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 CP 31398 dihydrochloride 的部分引用包括：

Grugan et al (2013) A common p53 mutation (R175H) activates c-Met receptor tyrosine kinase to enhance tumor cell invasion. Mol Cell Neurosci 14 853 PMID: 23792586

Roh et al (2011) p53-Reactivating small molecules induce apoptosis and enhance chemotherapeutic cytotoxicity in head and neck squamous cell carcinoma. Oral Oncol 47 8 PMID: 21109480

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Cell Cycle and DNA Damage Research Product Guide

This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:

Cell Cycle and Mitosis
DNA Damage Repair
Targeted Protein Degradation
Ubiquitin Proteasome Pathway
Chemotherapy Targets

Cell Cycle & DNA Damage Repair Poster

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.

Pathways for CP 31398 dihydrochloride

p53 Signaling Pathway

p53 signaling plays an important role in the co-ordination of the cellular response different types of stress such as DNA damage and hypoxia. The downstream signals lead to apoptosis, senescence and cell cycle arrest.