p53 Signaling Pathway
Cdk4/6 DNA-PK 14.3.3σ p53 p53 p53 JNK Chk2 Cdc2 Cdk2 Chk1 ATM ATR Akt Apoptosis Proteasomal
Degradation Nitric Oxide Cell Cycle
Arrest Mdm2 Mdm2
Degradation Nitric Oxide Cell Cycle
Arrest Mdm2 Mdm2
p53 signaling plays an important role in the co-ordination of the cellular response to different types of stress such as DNA damage and hypoxia. The downstream signals lead to apoptosis, senescence and cell cycle arrest. Inactivation of p53 has been implicated in tumor progression, it is thought that more than half of all cancers may involve p53-inactivating mutations.
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Signaling Pathway Key
Stimulates
Inhibits
Multistep Activation
Multistep Upregulation
Kinase
Transcription Factor
Other Enzyme
Other Protein
Proapoptotic
