CP 339818 hydrochloride

Name: CP 339818 hydrochloride
Brand: Tocris Bioscience
SKU: 1399
Rating: 5 (1 reviews)

Cat. No. 1399 1 次引用 1 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

1399 has been discontinued.

View all Voltage-gated Potassium (K<sub>V</sub>) Channels products.

说明： Non-peptide, potent K_V1.3 channel blocker

化学名： N-[1-(Phenylmethyl)-4(1H)-quinolinylidene]-1 pentanamine hydrochloride

纯度： ≥99% (HPLC)

说明书

引用文献 (1)

生物活性技术数据说明书参考文献

生物活性 for CP 339818 hydrochloride

CP 339818 hydrochloride is a potent, non-peptide K_V1.3 channel antagonist that preferentially binds to the C-type inactivated state of the channel (IC₅₀ ~ 200 nM). Inhibits K_V1.4 with an IC₅₀ of ~ 300 nM. Selective over K_V1.1, K_V1.2, K_V1.5, K_V1.6, K_V3.1-4, and K_V4.2.

技术数据 for CP 339818 hydrochloride

分子量	340.89
公式	C₂₁H₂₄N₂.HCl
储存	Store at RT
纯度	≥99% (HPLC)
CAS Number	478341-55-8
PubChem ID	20761468
InChI Key	JIRISCAPZWLWCG-UHFFFAOYSA-N
Smiles	CCCCC\N=C2C1=CC=CC=C1N(CC3=CC=CC=C3)C=C/2.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for CP 339818 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for CP 339818 hydrochloride

参考文献是支持产品生物活性的出版物。

Jager et al (1998) Regulation of mammalian Shaker-related K⁺ channels: evidence for non-conducting closed and non-conducting inactivated. J.Physiol. 506 291 PMID: 9490854

Nguyen et al (1996) Novel nonpeptide agents potently block the C-type inactivated conformation of Kv1.3 and suppress T cell activation. Mol.Pharmacol. 50 1672 PMID: 8967992

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1 篇 CP 339818 hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 CP 339818 hydrochloride 的部分引用包括：

Meredith et al (2015) Kv1 channels and neural processing in vestibular calyx afferents. J Neurosci 9 85 PMID: 26082693