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Submit ReviewCP 724714
说明： Potent and selective ErbB2 inhibitor
化学名： 2-Methoxy-N-[(2E)-3-[4-[[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]phenyl]amino]-6-quinazolinyl]-2-propen-1-yl]acetamide
纯度： ≥98% (HPLC)
生物活性 for CP 724714
CP 724714 is a potent and selective ErbB2 inhibitor (IC50 = 10 nM). Exhibits 500-1000-fold selectivity for ErbB2 over ErbB1 and other related RTKs. Induces G1 cell cycle arrest in an ErbB2-overexpressing human cancer cell line. Promotes tumor apoptosis. Induces tumor regression in a human tumor xenograft model. Displays no apparent toxic effect on cardiac tissue.
许可信息
Sold for research purposes under agreement from Pfizer Inc.
External Portal Information for CP 724714
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of CP-724714 is reviewed on the chemical probes website.
技术数据 for CP 724714
| 分子量 | 469.53 |
| 公式 | C27H27N5O3 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 383432-38-0 |
| PubChem ID | 9874913 |
| InChI Key | LLVZBTWPGQVVLW-SNAWJCMRSA-N |
| Smiles | CC1=CC(NC2=NC=NC3=CC=C(/C=C/CNC(COC)=O)C=C32)=CC=C1OC4=CC=C(C)N=C4 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for CP 724714
参考文献 for CP 724714
参考文献是支持产品生物活性的出版物。
Jani et al (2007) Discovery and pharmacologic characterization of CP-724,714, a selective ErbB2 tyrosine kinase inhibitor. Cancer Res. 67 9887 PMID: 17942920
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